Genomic imprinting has been recognized since the late 1970's and known to be involved in several inherited diseases, but only recently have the questions surrounding the mechanisms behind it been answered. This volume reviews the latest exciting developments, with full citations of the key bibliography, discussions of the major questions in the field and outlines of directions for future research. Chapters range from a discussion of the genetic analysis of DNA methylation to a comprehensive evaluation of evolutionary theories. In between lie discussions of sequence signals and their recognition during development, expositions of some of the best studied imprint genes, and a summary for methods of identification.
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
Dr Wolf Reik, The Babraham Institute, Babraham Hall, Babraham, Cambridge CB2 4AT. Email: wolf.reik@bbsrc.ac.uk Professor Azim Surani, Wellcome/CRC Institute, Cambridge
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