Fmoc Solid Phase Peptide Synthesis: A Practical Approach - Couverture souple

Couverture souple

ISBN 10 : 0199637245 ISBN 13 : 9780199637249

Editeur : Oxford University Press, U.S.A., 2000

Synopsis

In the years since the publication of Atherton and Sheppard's volume, the technique of F.M.O.C solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems outstanding at the time of publication of this earlier work have now been, for the most part, solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers not only the essential procedures for the production of linear peptides but also more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly and a survey of available automated instrumentation.

A propos du livre

Présentation de l'éditeur

In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now for the most part, been solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers the essential procedures for the production of linear peptides and more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly. Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as t-bag, SPOT and PIN synthesis, have naturally been included. Finally, a survey of available automated instrumentation has also been provided.

Revue de presse

'covers the essential procedures for the production of linear peptides, and the techniques for preparing cyclic, side-chain modified, phospho-and glycopeptides' Sciences de la vie

'..a completly fresh book.....a goldmine...' European Petide Society

Détails de l'édition

• Éditeur: Oxford University Press, U.S.A.
• Date d'édition: 2000
• Langue: anglais
• ISBN 10: 0199637245
• ISBN 13: 9780199637249
• Reliure: Broché
• Nombre de pages: 376
• Éditeur: Chan W. C.
• Coordonnées du fabricant: non disponible
• Personne responsable: Ufficio Anagrafiche Messaggerie; ufficio.anagrafiche@meli.it; ; Via Verdi, 8; Assago Milano; 20090; Italie