The Cytoskeleton: A Target for Toxic Agents - Couverture rigide

Clarkson, Thomas W.; Sager, Polly R.; Syversen, Tore L.M.

Couverture rigide

ISBN 10 : 0306422050 ISBN 13 : 9780306422058

Editeur : Kluwer Academic / Plenum Publishers, 1999

Synopsis

This book is based on reviews and research presentations given at the 16th Rochester International Conference on Environmental Toxicity, entitled liThe Cytoskeleton: A Target for Toxic Agents," held on June 4, 5 and 6 in 1984. The conference provided an in-depth discussion of the effects a d mechanism of action of some toxic agents on the cytoskeleton. Mamma"lian and other eukaryotic cells contain protein networks within the cytoplasm comprised of microfilaments, intermediate Hlaments and microtubules. These components of the cytoskeleton playa key role in cell shape, motility, intracellular organization and transport, and cell division. Furthermore, the cytoskeleton, via associations with the cell membrane, appears to function in intracellular communication and cellular responses to membrane events. Because of the complex functional roles of the cytoskeleton which vary with cell type, degree of differentiation, and cell cycle, its disruption may result in a variety of cellular changes. This expanding field in cell biology has already attracted the interest of toxicologists and environmental health scientists as a potentially fruitful area of research. Indeed, there is mounting evidence that certain toxic and chemotherapeutic compounds, as well as physical agents such as radiation and hydrostatic pressure, disrupt the normal structure and function of the cytoskeleton. This may be an important step in the overall expression of their action. It was, therefore, an opportune time to hold a conference to encourage the development of this area of toxicology and to suggest directions for future research.

Détails de l'édition

• Éditeur: Kluwer Academic / Plenum Publishers
• Date d'édition: 1999
• Langue: anglais
• ISBN 10: 0306422050
• ISBN 13: 9780306422058
• Reliure: Relié
• Nombre de pages: 261
• Coordonnées du fabricant: non disponible
• Personne responsable: CMN Printpool Inh. Mathis Neumann; https://www.also.com/ec/cms5/en_6000/6000/index.jsp; ; Friedrich-Karl-Str. 9; Hamburg; Allemagne