Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells - Couverture rigide

Couverture rigide

ISBN 10 : 0306434261 ISBN 13 : 9780306434266

Editeur : Plenum Publishing Co.,N.Y., 1990

Synopsis

This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther- modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem- brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at thermodynamic equilibrium. These two observations were gener- alized and virtually all cells were thought to have a very high P Cl and a ther- modynamically passive Cl- transmembrane distribution. These concepts can still be found in some physiology and neuroscience textbooks.

Détails de l'édition

• Éditeur: Plenum Publishing Co.,N.Y.
• Date d'édition: 1990
• Langue: anglais
• ISBN 10: 0306434261
• ISBN 13: 9780306434266
• Reliure: Relié
• Nombre de pages: 444
• Éditeur: Alvarez-Leefmans F.J., Russell John M.
• Coordonnées du fabricant: non disponible
• Personne responsable: CMN Printpool Inh. Mathis Neumann; https://www.also.com/ec/cms5/en_6000/6000/index.jsp; ; Friedrich-Karl-Str. 9; Hamburg; Allemagne