Articles liés à Ecto-Atpases: Recent Progress on Structure and Function

Ecto-Atpases: Recent Progress on Structure and Function - Couverture rigide

International Workshop On Ecto-Atpases 1996 (Mar De Plata, Argentina)

 
9780306455841: Ecto-Atpases: Recent Progress on Structure and Function
Couverture rigide
ISBN 10 : 0306455846 ISBN 13 : 9780306455841
Editeur : Kluwer Academic / Plenum Publishers, 1997

Synopsis

It has been known for almost 50 years that many cells carry enzymes that hydro­ lyze extracellular ATP, and the term "ecto-ATPase" was used first by Engelhardt 40 years ago. But until the end of the 1970's, the idea of an ATPase with its ATP hydrolyzing site on the outside of the cell membrane was met with substantial skepticism since it was thought that ATP was strictly intracellular. Nevertheless, ecto-ATPase activity was dem­ onstrated using a variety of intact cells. Most ecto-ATPase(s) exhibited three common 2 characteristics: 1) activation by either Ca + or Mg2+, 2) insensitivity to the commonly used inhibitors ofF-type, P-type, and V-type ATPases, and 3) ability to hydrolyze nucleo­ side triphosphates and often nucleoside diphosphates as well. At the same time, the dominant ATPase activity in many plasma membrane preparations was shown to be dis­ tinct from the ion-pump ATPases, but had similar enzymatic properties as the ecto-AT­ Pase(s). Thus the term "E-type ATPase activity" has been proposed for ATPase activity exhibiting these characteristics, and it is assumed that all ecto-ATPases are E-type AT­ Pases. The converse is not true, however, since soluble E-type ATPases were shown to ex­ sist in plants, microorganisms, and the saliva of blood sucking insects. These enzymes could be easily purified, and exhibited very high specific activity.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
Kluwer Academic / Plenum Publishers
Date d'édition
1997
Langue
anglais
ISBN 10 
0306455846
ISBN 13 
9780306455841
Reliure
Relié
Nombre de pages
294
Éditeur
Plesner Liselotte, Kirley Terence L., Knowles Aileen F.
Coordonnées du fabricant
non disponible
Personne responsable
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