This book examines the principles underlying genetic predisposition to cancer in order to familiarise practising oncologists, geneticists and other professionals interested in cancer with this new and expanded field. The coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the detection and cloning of predisposition genes to a consideration of familial cancer syndromes, encompassing rare and common cancers. The text also includes a discussion of genetic screening and cancer management options, and a consideration of the associated ethical and psychological issues. To reflect the rapid advances in the field since the first edition, the contents have been thoroughly updated with new chapters on the biological basis of cancer predisposition, population-based studies of susceptibility, Von-Hippel-Lindau syndrome and evaluation of management strategies for individuals at increased cancer risk.
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Rosalind A. Eeles is Clinical Senior Lecturer and Honorary Consultant in Cancer Genetics and Clinical Oncology; Team Leader, Translation Cancer Genetics Team, Institute of Cancer Research; and Head, Cancer Genetics Unit, Royal Marsden NHS Trust, Sutton, UK
Douglas F. Easton is Director, Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
Bruce A. J. Ponder is Cancer Research UK Professor of Oncology; Director, Cancer Research UK Human Genetics Research Group; and Co-Director, Hutchison-MRC Research Centre and Strangeways Laboratory for Genetic Epidemiology, University of Cambridge, UK
Charis Eng is Dorothy E. Klotz Chair of Cancer Research; William C. and Joan E. Davis Professor of Cancer Research; Professor & Director, Division of Human Genetics, Department of Internal Medicine; and Director, Clinical Cancer Genetics Program, The Ohio State University, Columbus, Ohio, USA
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