Statistical Methods in Drug Combination Studies - Couverture souple

Livre 48 sur 155: Chapman & Hall/CRC Biostatistics
 
9780367738624: Statistical Methods in Drug Combination Studies
Couverture souple
ISBN 10 : 0367738627 ISBN 13 : 9780367738624
Editeur : Routledge, 2020

Synopsis

The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods in in vitro and in vivo drug combination assessments. However, despite these advances, no book has served as a single source of information for statistical methods in drug combination research, nor has there been any guidance for experimental strategies.



Statistical Methods in Drug Combination Studies

fills that gap, covering all aspects of drug combination research, from designing in vitro

drug combination studies to analyzing clinical trial data. Featuring contributions from researchers in industry, academia, and regulatory agencies, this comprehensive reference:





  • Describes statistical models used to characterize dose–response patterns of monotherapies and evaluate the combination drug synergy


  • Offers guidance for estimating interaction indices and constructing their associated confidence intervals to assess drug interaction


  • Introduces a practical and innovative Bayesian approach to Phase I cancer trials, including actual trial examples to illustrate use


  • Examines strategies in the fixed-dose combination therapy clinical development via case studies stemming from regulatory reviews


  • Evaluates computational tools and software packages used to apply novel statistical methods in combination drug development


Statistical Methods in Drug Combination Studies provides researchers with a solid understanding of the available statistical methods and computational tools and how to apply them in drug combination studies. The book is equally useful for statisticians to become better equipped to deal with drug combination study design and analysis in their practice.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l?auteur

Wei Zhao, Harry Yang

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Routledge
Date d'édition
2020
Langue
anglais
ISBN 10 
0367738627
ISBN 13 
9780367738624
Reliure
Broché
Nombre de pages
240
Éditeur
Zhao Wei, Yang Harry
Coordonnées du fabricant
non disponible
Personne responsable
non disponible

Autres éditions populaires du même titre

9781482216745: Statistical Methods in Drug Combination Studies

Edition présentée

ISBN 10 :  1482216744 ISBN 13 :  9781482216745
Editeur : Chapman & Hall/CRC, 2014
Couverture rigide