The Cancer Degradome: Proteases and Cancer Biology - Couverture rigide

Couverture rigide

ISBN 10 : 0387690565 ISBN 13 : 9780387690568

Editeur : Springer-Verlag New York Inc., 2008

Synopsis

Proteolysis is essential for life. From the breakdown of proteins in food for biosynthesis, through to antigen processing in the immune system, the blood cl- ting cascade, and the hormone-regulated remodelling of female reproductive tissues in adult mammals - proteolysis governs functionality, homeostasis, and fate at the levels of the cell and the entire organism. For the cancer cell, intracellular prote- ysis carried out by caspases and the proteasome must be enlisted and controlled to allow it to escape apoptosis. Functioning on the cancer cell surface or in the extracellular milieu, secreted proteases (primarily metalloproteinases, serine p- teases, and cathepsins) determine the interactions of cells with their environments. Once considered simply as promoting tumour cell invasion through tissue barriers, proteolysis is now known to be integral to many aspects of cancer biology, including angiogenesis, regulation of the bioavailability of growth factors, cellular adhesion, cytokine/chemokine signalling, in?ammatory cell recruitment, and the mobilization of normal cells from their tissue compartments to act as accomplices in metastasis. The last decade has witnessed a revolution in our thinking concerning the role of extracellular proteolysis in cancer biology: this is the primary focus of this book.

Détails de l'édition

• Éditeur: Springer-Verlag New York Inc.
• Date d'édition: 2008
• Langue: anglais
• ISBN 10: 0387690565
• ISBN 13: 9780387690568
• Reliure: Relié
• Nombre de pages: 949
• Éditeur: Edwards Dylan, Hoyer-Hansen Gunilla, Blasi Francesco, Sloane B.F.
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne