Functional Tissue Engineering - Couverture rigide

Couverture rigide

ISBN 10 : 0387955534 ISBN 13 : 9780387955537

Editeur : Springer-Verlag New York Inc., 2003

Synopsis

The goal of tissue engineering is to repair or replace tissues and organs by delivering implanted cells, scaffolds, and/or macromolecules during surgery. Tissue engineers, however, have faced significant challenges in repairing or replacing tissues that serve a biomechanical function. This book discusses the issues facing bioengineers seeking reliable methods of effectively repairing or replacing these load-bearing structures. It will be useful to students and researchers and will serve as a useful reference and teaching text for the rapidly increasing population of those in the field of tissue engineering.

A propos du livre

À propos de la quatrième de couverture

The goal of "tissue engineering" is to repair or replace tissues and organs by delivering implanted cells, scaffolds, DNA, proteins, and/or protein fragments at surgery. Tissue engineering merges aspects of engineering and biology, and many rapid achievements in this field have arisen in part from significant advances in cell and molecular biology.

Despite its early successes, however, tissue engineers have faced challenges in repairing or replacing tissues that serve a predominantly biomechanical function. This book addresses and discusses a number of issues that need to be addressed in order for tissue engineers to effectively repair or replace these load-bearing structures. What are the thresholds of force, stress, and strain that normal tissues transmit or encounter? What are the mechanical properties of these tissues when subjected to expected in vivo stresses and strains, as well as under failure conditions? Which of these properties should a tissue engineer insist upon incorporating into the design? Do tissue engineered repairs and replacements need to exactly duplicate the structure and function of the normal tissue or organ in order to be successful? When developing these implants in culture, how do physical factors such as mechanical stress regulate cell behavior in bioreactors as compared to signals experienced in vivo? And finally, can tissue engineers mechanically stimulate these implants before surgery to produce a better repair outcome?

Chapters written by well-known researchers discuss these matters and provide guidelines and a summary of the current state of technology in functional tissue engineering. The book will be useful to students and researchers as it will increase awareness among tissue engineers of the importance of restoring "function" when engineering tissue constructs, and identifying the critical structural and mechanical requirements needed for each construct. It will also providean invaluable source of information to help tissue engineers incorporate these functional criteria into the design, manufacture, and optimization of tissue engineered products. Finally it serves as a reference and teaching text for the rapidly increasing population of students and investigators in the field of tissue engineering.

Détails de l'édition

• Éditeur: Springer-Verlag New York Inc.
• Date d'édition: 2003
• Langue: anglais
• ISBN 10: 0387955534
• ISBN 13: 9780387955537
• Reliure: Relié
• Nombre de pages: 426
• Éditeur: Guilak Farshid, Butler PH.D. David L, Goldstein MD Facc Steven A, Mooney David
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne