Genome Chaos - Couverture souple

Heng

 
9780443154287: Genome Chaos
Couverture souple
ISBN 10 : 0443154287 ISBN 13 : 9780443154287
Editeur : Academic Press, 2025

Synopsis

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities where the genome, rather than individual genes, defines system-level inheritance and represents a clear unit of selection for macroevolution. In this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.

In this timely new edition, Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research. Ten evidence-based chapters discuss 4D genomics, genes and genomes as distinct biological entities, genome chaos and cellular macroevolution, karyotype coding and fuzzy inheritance, as well as an entirely novel model of evolution driven by information flow, and more. Brand-new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary framework. This synthesis offers a revolutionary paradigm of evolutionary theory. It also hypothesizes about how information flow, matter arrangement, and energy interact.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l?auteur

Dr. Henry H. Heng has coauthored over 200 publications and serves on the editorial boards of seven international, peer-reviewed journals. Using single-cell analysis of in vitro and in vivo models, Dr. Heng's group has illustrated the evolutionary dynamics of cancer progression by directly observing evolution in action. Such experiments revealed that cancer evolution involves two phases: punctuated genome alteration-mediated macroevolution (which creates a new system), followed by stepwise gene and epigenetic-mediated microevolution (which leads to population growth). By applying this concept to organismal evolution, he discovered that the main function of sex is to reduce genetic diversity at the genome level in order to preserve genome-defined species identity information. Heng introduced the Genome Architecture Theory, a new genome-based conceptual framework of genomics and evolution.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Academic Press
Date d'édition
2025
Langue
anglais
ISBN 10 
0443154287
ISBN 13 
9780443154287
Reliure
Broché
Numéro d'édition
2
Nombre de pages
750
Coordonnées du fabricant
Academic Press
https://shop.elsevier.com/

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