Structural and Evolutionary Genomics: Natural Selection in Genome Evolution - Couverture rigide

Bernardi, Giorgio

Couverture rigide

ISBN 10 : 0444512551 ISBN 13 : 9780444512550

Editeur : Elsevier Science Ltd, 2004

Synopsis

Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a regional control is exerted by natural selection (essentially negative or purifying selection). A neo-selectionist model is proposed for genome evolution.

Détails de l'édition

• Éditeur: Elsevier Science Ltd
• Date d'édition: 2004
• Langue: anglais
• ISBN 10: 0444512551
• ISBN 13: 9780444512550
• Reliure: Relié
• Nombre de pages: 342
• Coordonnées du fabricant: non disponible
• Personne responsable: Barbara Criscuolo; b.criscuolo@lswr.it; ; Via Spadolini, 7; Milano; 20141; Italie