Sleep and Aging (Volume 17) (Advances in Cell Aging & Gerontology, Volume 17) - Couverture rigide

Couverture rigide

ISBN 10 : 0444518762 ISBN 13 : 9780444518767

Editeur : Elsevier Science Ltd, 2005

Synopsis

Alterations in sleep are common manifestations of aging that can lead to significant health problems and contribute to behavioural problems associated with age-related neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Recent advances have revealed key cellular and molecular mechanisms involved in sleep regulation, and this knowledge is helping to advance an understanding of both the normal functions of sleep and the mechanisms responsible for abnormalities in sleep in various neurological conditions and during normal aging. This volume of Advances in Cell Aging and Gerontology brings together chapters by leaders in the fields of sleep research and the neurobiology of aging. The book starts with chapters describing fundamental aspects of the neurocircuitry involved in sleep, patterns of brain activity during the different stages of sleep and disturbances of sleep during aging. The links between depression, anxiety and insomnia are reviewed in regards to the underlying neurochemical alterations that appear to involve abnormalities in neurotransmitter and neurotrophic factor signalling. The evolutionary basis of sleep is reviewed and the emerging evidence supporting a major role for sleep in learning and memory is described. The bulk of the book focuses on specific sleep disorders associated with aging and age-related neurodegenerative disorders. A comprehensive consideration of this topic is woven through a number of chapters that address both basic research and clinical aspects of sleep abnormalities during aging and in disease. The impact of sleep on the immune system is described. The articles are written in a high level of detail and are comprehensive, thus providing valuable information for a range of scientists and other well-educated people. In particular, the book will be a valuable resource for graduate students, postdoctoral and senior scientists in the fields of sleep, aging, neurodegenerative disorders and learning and memory. In addition, clinicians will find this book valuable as it provides a bridge between basic research and the treatment of the patients with sleep disorders.

A propos du livre

À propos de l?auteur

Dr. Mattson is a Professor of Neuroscience at Johns Hopkins University School of Medicine. After receiving his PhD degree from the University of Iowa, Dr. Mattson completed a postdoctoral fellowship in Developmental Neuroscience at Colorado State University. He then joined the Sanders-Brown Center on Aging at the University of Kentucky College of Medicine where he advanced to Full Professor. From 2000-2019 Dr. Mattson was the Chief of the Laboratory of Neurosciences at the National Institute on Aging in Baltimore where he brought neuroscience research to the forefront at that NIH Institute. Dr. Mattson’s research is aimed at understanding molecular and cellular mechanisms of brain aging and the pathogenesis of neurodegenerative disorders. His work has elucidated how the brain responds adaptively to challenges such as fasting and exercise, and he has used that information to develop novel interventions to promote optimal brain function throughout life. Dr. Mattson is among the most highly cited neuroscientists in the world with over 150,000 citations and an ‘h’ index of over 200. He was elected a Fellow of the American Association for the Advancement of Science, and has received many awards including the Metropolitan Life Foundation Medical Research Award, the Alzheimer’s Association Zenith Award and the Santiago Grisolia Chair Prize. He was the founding Editor and Editor-in-Chief of Ageing Research Reviews and Neuromolecular Medicine, and is currently a Reviewing or Associate Editor for the Journal of Neuroscience and Trends in Neurosciences.

À propos de la quatrième de couverture

Sleep and Aging provides a unique and timely collection of review articles that cover the gamut of basic and clinical aspects of sleep and the abnormalities in sleep associated with aging and neurological disorders that occur during aging. From the evolutionary basis of sleep and its normal functions in processes such as learning and memory, to considerations of the roles of sleep abnormalities in neurological disorders such as depression, Alzheimer s and Parkinson s diseases, the chapters are written by experts in the field. Several chapters focus on signalling pathways involved in sleep regulation and abnormalities in sleep, including those activated by serotonin and BDNF. Basic and clinical research on insomnia, sleep apnea and other disorders of sleep, are covered thus providing students and scientists at all levels with a valuable source of information to advance their understanding of this important topic in aging, biology and medicine. The circuits in the brain involved in sleep regulation, their neurochemistry, how they are altered in disorders of sleep and current clinical treatments of various sleep disorders are reviewed. The important role of sleep disturbances in neurodegenerative disorders is described and research in this particular area is leading to a better understanding of the relationships between synaptic plasticity, neuronal degeneration and the clinical manifestations of disorders such as Alzheimer s disease, Parkinson s disease and depression. This book is a must for scientists, as well as non-scientists, who are interested in the neurobiology of aging, sleep and neurodegenerative disorders.|Sleep and Aging provides a unique and timely collection of review articles that cover the gamut of basic and clinical aspects of sleep and the abnormalities in sleep associated with aging and neurological disorders that occur during aging. From the evolutionary basis of sleep and its normal functions in processes such as learning and memory, to considerations of the roles of sleep abnormalities in neurological disorders such as depression, Alzheimer s and Parkinson s diseases, the chapters are written by experts in the field. Several chapters focus on signalling pathways involved in sleep regulation and abnormalities in sleep, including those activated by serotonin and BDNF. Basic and clinical research on insomnia, sleep apnea and other disorders of sleep, are covered thus providing students and scientists at all levels with a valuable source of information to advance their understanding of this important topic in aging, biology and medicine. The circuits in the brain involved in sleep regulation, their neurochemistry, how they are altered in disorders of sleep and current clinical treatments of various sleep disorders are reviewed. The important role of sleep disturbances in neurodegenerative disorders is described and research in this particular area is leading to a better understanding of the relationships between synaptic plasticity, neuronal degeneration and the clinical manifestations of disorders such as Alzheimer s disease, Parkinson s disease and depression. This book is a must for scientists, as well as non-scientists, who are interested in the neurobiology of aging, sleep and neurodegenerative disorders.

Détails de l'édition

• Éditeur: Elsevier Science Ltd
• Date d'édition: 2005
• Langue: anglais
• ISBN 10: 0444518762
• ISBN 13: 9780444518767
• Reliure: Tapa dura
• Nombre de pages: 204
• Éditeur: Mattson Mark P.
• Coordonnées du fabricant: non disponible
• Personne responsable: Barbara Criscuolo; b.criscuolo@lswr.it; ; Via Spadolini, 7; Milano; 20141; Italie