The hERG Cardiac Potassium Channel: Structure, Function And Long QT Syndrome - Couverture rigide

Couverture rigide

ISBN 10 : 0470021403 ISBN 13 : 9780470021408

Editeur : John Wiley & Sons Inc, 2005

Synopsis

This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. 

It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. 

Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

A propos du livre

À propos de l?auteur

The Novartis Foundation is an international scientific and educational charity that promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Détails de l'édition

• Éditeur: John Wiley & Sons Inc
• Date d'édition: 2005
• Langue: anglais
• ISBN 10: 0470021403
• ISBN 13: 9780470021408
• Reliure: Relié
• Nombre de pages: 308
• Éditeur: Chadwick Derek J., Goode Jamie A.
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible