Articles liés à Protein Surface Recognition: Approaches for Drug Discovery

Protein Surface Recognition: Approaches for Drug Discovery - Couverture rigide

 
9780470059050: Protein Surface Recognition: Approaches for Drug Discovery
Couverture rigide
ISBN 10 : 0470059052 ISBN 13 : 9780470059050
Editeur : John Wiley & Sons Inc, 2010

Synopsis

A new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key cellular processes related to human disease.

Protein Surface Recognition presents a detailed treatment of this strategy, with topics including:

  • an extended survey of protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspective
  • the fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfaces
  • examples of protein surface-small molecule interactions, including treatments of protein-natural product interactions, protein-interface peptides, and rational approaches to protein surface recognition from model to biological systems
  • a survey of techniques that will be integral to the discovery of new small molecule protein surface binders, from high throughput synthesis and screening techniques to in silico and in vitro methods for the discovery of novel protein ligands.

Protein Surface Recognition provides an intellectual "tool-kit" for investigators in medicinal and bioorganic chemistry looking to exploit this emerging paradigm in drug discovery.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l'auteur

ERNEST GIRALT, Department of Organic Chemistry, University of Barcelona and Institute for Research in Biomedicine, Barcelona, Spain

MARK PECZUH, Department of Chemistry, University of Connecticut, USA

XAVIER SALVATELLA, ICREA and Institute for Research in Biomedicine, Barcelona, Spain

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
John Wiley & Sons Inc
Date d'édition
2010
Langue
anglais
ISBN 10 
0470059052
ISBN 13 
9780470059050
Reliure
Relié
Nombre de pages
344
Éditeur
Giralt Ernest, Peczuh Mark, Salvatella Xavier
Coordonnées du fabricant
non disponible
Personne responsable
non disponible