Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications - Couverture rigide

 
9780470275009: Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications
Couverture rigide
ISBN 10 : 0470275006 ISBN 13 : 9780470275009
Editeur : John Wiley & Sons Inc, 2009

Synopsis

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes

The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context.

With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as:

  • Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G

  • Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions

  • Cross reactivity of zinc-enzyme inhibitors and activators

  • The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins

  • Clinical applications

An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l?auteur

Claudiu T. Supuran is a professor in the Department of Chemistry at the University of Florence, Italy. His main research interests include medicinal chemistry, design of enzyme inhibitors and activators, X-ray crystallography of metallo-enzymes, and metal complexes with biologically active ligands (metal-based drugs). He has published more than 400 original research papers in these fields.

Jean-Yves Winum is an assistant professor in the Department of Chemistry at the University of Montpellier 2 (Institut des Biomolécules Max Mousseron UMR CNRS 5247), France. His research interests are focused on organic/medicinal chemistry of metallo-enzyme inhibitors and activators.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
John Wiley & Sons Inc
Date d'édition
2009
Langue
anglais
ISBN 10 
0470275006
ISBN 13 
9780470275009
Reliure
Relié
Numéro d'édition
1
Nombre de pages
1056
Éditeur
Supuran Claudiu T., Winum Jean-Yves
Coordonnées du fabricant
non disponible
Personne responsable
non disponible