Protective Groups in Organic Synthesis - Couverture rigide

Greene, Theodora W.; Wuts, Peter G.M.

Couverture rigide

ISBN 10 : 0471623016 ISBN 13 : 9780471623014

Editeur : John Wiley & Sons Inc, 1991

Synopsis

A frequent requirement in organic synthesis is the protection of one or more of the major functional groups - the hydroxyl, amino, carboxyl, carbonyl and sulfhydryl groups. For these major functional groups, this book provides concise, comprehensive coverage of the most useful protective groups. For each functional group, a short section discusses the chemistry of the classes of protective groups that are available. The chemistry of the individual protective groups in the class is then described using structures, equations and references.

A propos du livre

Quatrième de couverture

The Most Comprehensive Guide to Protective Groups in Organic Synthesis Currently Available For more than twenty–five years, Protective Groups in Organic Synthesis has been the definitive guide for organic chemists in designing synthetic routes. Now in its fourth edition, the text continues to be a uniquely comprehensive and an indispensable reference for both synthetic organic and medicinal chemists who want to control the reactivity of the most common functional groups during a synthetic sequence. The Fourth Edition includes significant developments in protective group chemistry since 1998. In addition to incorporating new protective groups now available to the synthetic organic chemist, such as the uniquely removable 2–methoxybenzenesulfonyl group for the protection of amines, the book also covers new techniques for the formation and cleavage of existing protective groups, providing the most relevant and useful examples to illustrate each methodology. The content is organized around the functional group to be protected (ethers, acids, carbonyl groups, amines, amides, phenols, etc.), and ranges from the simplest to the most complex highly specialized protective groups. New features of the Fourth Edition include: The addition of numerous new protective groups, such as the fluorous family New methods for the cleavage and introduction of many of the classic protective groups highlighting selectivity issues when reported in the literature Expanded coverage of the unexpected side reactions that occur with protective groups A new chart covering the selective deprotection of silyl ethers 3,100 new references from the professional literature, complete through the end of 2005

Présentation de l'éditeur

From the reviews of the previous editions:
∗ "For completeness, the authors . . . include protective groups and techniques for formation and cleavage that are seldom used as well as those that are more common. . . . Anyone who does organic synthesis must have convenient access to this book." –Journal of the American Chemical Society.
∗ "Essential to the modern synthetic organic chemist . . . should be in the libraries of all academic, governmental, and industrial organizations concerned with organic synthesis." –Polymer News.

Reflecting the latest advances in protective group methodology, this Third Edition of the proven laboratory reference is expanded by more than 50%, providing readers with a comprehensive compendium of 1,050 of the most useful protective groups as well as 5,350 references to original publications. Protective groups are organized by six major organic functional groups: hydroxyl, amino, carboxyl, carbonyl, sulfhydryl, and phosphate groups (the last new to this edition). Also added in this edition are protection of the alkyne–CH, expanded coverage of protection of all groups, and many new enzymatic methods of protection and deprotection. Each chapter briefly describes the classes of available protective groups, followed by an in–depth look at the chemistry of individual protective groups, their properties, and the best methods of formation and cleavage. Ten reactivity charts with more than 28,000 entries summarize the relative reactivities of 270 commonly used protective groups with 108 reagents. This book will be an indispensable reference for synthetic chemists and students.

Détails de l'édition

• Éditeur: John Wiley & Sons Inc
• Date d'édition: 1991
• Langue: anglais
• ISBN 10: 0471623016
• ISBN 13: 9780471623014
• Reliure: Relié
• Numéro d'édition: 2
• Nombre de pages: 492
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible