Autoimmunity and Autoimmune Disease - Couverture rigide

Peters, D.K.

Couverture rigide

ISBN 10 : 0471910953 ISBN 13 : 9780471910954

Editeur : John Wiley & Sons Ltd, 1987

Synopsis

Autoimmune processes are proving to be underlying or contributory causes of increasing numbers of serious human disorders, including diabetes mellitus, Graves' disease, myasthenia gravis and rheumatoid arthritis. This symposium focuses on the advances in our basic understanding of the immune response and its regulation that are enabling specific, rational immunotherapy to be developed for these diseases. The nature of intracellular and cell surface-derived self antigens is considered here. Studies of murine autoimmune myocarditis are described in which cardiac myosin is identified as the autoantigen. Competing theories of the generation of immune tolerance are discussed, together with the implications of current ideas about immunoregulatory networks and the question of whether autoimmunity is a state of over-activity of the immune system or one of under- activity. Other chapters consider the exploitation of the immunoregulatory network in the treatment of experimental interstitial nephritis and other autoimmune conditions. The contributions of interferons and of class II HLA antigen expression to autoimmunity are presented. Suggested links between autoimmunity and immunodeficiency, and between autoimmunity and genetic complement deficiency, are also debated. The use of monoclonal anti-Ia antibodies to treat animal models of human autoimmune conditions suggests a way forward therapeutically, and the symposium ends with an assessment of the future of the immunoregulatory approach to diseases such as antiglomerular membrane disease, the systemic vasculitides, rheumatoid arthritis and multiple sclerosis.

A propos du livre

Présentation de l'éditeur

This work focuses on the autoimmune processes that have now been proven to underlie a number of serious diseases, including diabetes mellitus, rheumatoid arthritis and multiple sclerosis. Papers explore the rapidly expanding developments in research on immune response and regulation, and their potential in the development of treatments for autoimmune diseases. The wide range of subjects covered here include: the nature of intracellular and cell surface–derived ``self′′ antigens; competing theories of the generation of immune tolerance and their implications of current theories for research and treatment; possible links between autoimmunity and genetic complement deficiency; the contributions of interferons and class II HLA antigen expression to autoimmunity; and the potential of monoclonal antibodies and other biotechnological advances in treating human autoimmune conditions.

Détails de l'édition

• Éditeur: John Wiley & Sons Ltd
• Date d'édition: 1987
• Langue: anglais
• ISBN 10: 0471910953
• ISBN 13: 9780471910954
• Reliure: Relié
• Numéro d'édition: 1
• Nombre de pages: 288
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible