Chirality in Industry II: Developments in the Manufacture and Applications of Optically Active Compounds - Couverture rigide

Collins, A. N.; Etc.

Couverture rigide

ISBN 10 : 0471966800 ISBN 13 : 9780471966807

Editeur : John Wiley & Sons Ltd, 1997

Synopsis

The manufacture and applications of chiral compounds continue to develop. Building on the "case studies" format of the first volume, this text concentrates on different syntheses and the developments in the field. It presents a comprehensive picture of the technologies required for the production of optically active molecules on the multi-Kg to high tonnage scales, as well as illustrating the breadth of application of the products of these technologies. This volume is divided into sections on physical methods and classical resolutions, biological methods and the chiral pool, and asymmetric synthesis. These are preceded by a chapter dealing with regulatory issues for chiral drugs and two chapters on chiral drug development which illustrates how widely the industrial practitioner must cast the net in pursuit of practical production methods. The book should be of interest to applied chemists and organic synthetic chemists.

A propos du livre

Présentation de l'éditeur

This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up–to–date and comprehensive picture of the technologies required to produce optically active compounds on a multi–kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II
∗ All new case histories

∗ Unique industrial perspective on chiral technology

∗ Emphasis on scale–up and process development

∗ Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches
The chiral infrastructure is now largely in place and there is no reason why large–scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale–up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large–scale thinking. An economic solution is still most likely to be a simple, elegant solution.

Détails de l'édition

• Éditeur: John Wiley & Sons Ltd
• Date d'édition: 1997
• Langue: anglais
• ISBN 10: 0471966800
• ISBN 13: 9780471966807
• Reliure: Relié
• Nombre de pages: 416
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible