Gap Junction-Mediated Intercellular Signalling in Health and Disease - Couverture rigide

CIBA Foundation Symposium

Couverture rigide

ISBN 10 : 0471982598 ISBN 13 : 9780471982593

Editeur : John Wiley & Sons Ltd, 1999

Synopsis

Gap junction-mediated communication is essential for normal embryonic development and function in adult organs. Highlighting the progress in understanding gap junction structure, this concise volume discusses the specific roles of individual connexins (gap junction proteins). It brings together an interdisciplinary group of experts, who review the role of gap junctions in cell proliferation and cancer, the retina and lens, the auditory system, the heart, the central and peripheral nervous system, and the reproductive system.

A propos du livre

Quatrième de couverture

Gap Junction–Mediated Intercellular Signalling in Health and Disease Chairman: Norton B. Gilula 1999 The last few years have seen considerable progress in this field, and exciting new implications concerning the roles of gap junctional intercellular communication are being raised. It is clear that good communication is essential for normal embryonic development and function in adult organs, although the individual functions of the proteins that form channels (connexins) are not yet fully understood. It is an exciting time in the gap junction field because the associations between failures in gap junction communication and resultant diseases are beginning to emerge. For example, mutations in the major connexin of the heart (C×43) have been found in human patients suffering from visceroatrial heterotaxia syndrome, and mutations in the gene encoding C×32 have been found in patients suffering from Charcot–Marie–Tooth disease. This book is the first of its kind to highlight the recent progress in understanding gap junction structure, and discuss the specific roles of individual connexins. It brings together an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and cell proliferation and cancer. It will appeal to all those interested in cell biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.

Présentation de l'éditeur

Gap junctions are key elements in communication between cells in multicellular organisms.  It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood.

The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot–Marie–Tooth disease.

This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer.

The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.

Détails de l'édition

• Éditeur: John Wiley & Sons Ltd
• Date d'édition: 1999
• Langue: anglais
• ISBN 10: 0471982598
• ISBN 13: 9780471982593
• Reliure: Relié
• Nombre de pages: 296
• Éditeur: Gilula Norton B.
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible