Smith and Williams' Introduction to the Principles of Drug Design - Couverture rigide

Smith, H. John; Williams, Hywel

Couverture rigide

ISBN 10 : 0723612110 ISBN 13 : 9780723612117

Editeur : Butterworth-Heinemann Ltd, 1988

A propos du livre

Présentation de l'éditeur

Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion.

See what’s new in the Fourth Edition:

Fully updates and expands the contents

Coverage of agonists and antagonists of neuro-transmitters

Information on the design of stable peptide-like drugs

The human genome and its impact on drug discovery and development

Advances in therapy and pharmacokinetics

Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.

Présentation de l'éditeur

The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach.
As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated.

The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials

Détails de l'édition

• Éditeur: Butterworth-Heinemann Ltd
• Date d'édition: 1988
• Langue: anglais
• ISBN 10: 0723612110
• ISBN 13: 9780723612117
• Reliure: Relié
• Numéro d'édition: 2
• Nombre de pages: 384
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible