This volume presents research advances that provide novel strategies for developing or accelerating both preventive and therapeutic efforts against HIV. Addressing the most important long- and short-term issues, "AIDS Research Reviews: Volume 3": supplies a comprehensive analysis of two HIV viral proteins, Tat and Rev, that modulate gene expression; discusses possible strategies for attacking HIV at the transcriptional level; demonstrates the potential utility of feline immunodeficiency virus as a small-animal model for HIV pathogenesis and vaccine design; reviews models for HIV pathogenesis and suggests that HIV-induced AIDS may result from immunological consequences similar to those of graft-versus-host disease; details the fine specificity of the host immune response to HIV infection; examines the therapeutic potential of various combinations of antibodies; and focuses on the challenges of "vaccine development" related to mucosal immunity and describes new poxvirus vectors for vaccine design. With over 1830 literature citations, figures, and tables, "AIDS Research Reviews: Volume 3" is for microbiologists and virologists; molecular and cell biologists; immunologists; hematologists; oncologists; infectious disease specialists; pharmacologists; medicinal chemists, biochemists, and biotechnologists; parasitologists; and pathologists.
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