Structural Biology of DNA Damage and Repair - Couverture rigide

Couverture rigide

ISBN 10 : 0841225745 ISBN 13 : 9780841225749

Editeur : Oxford University Press Inc, 2011

Synopsis

The human genome is continuously exposed to many classes of genotoxins. Of these, three that will be discussed herein include 5,6-dihydroxy-5,6- dihydrothymine (thymine glycol; Tg), O6-methylguanine (O6MeG), and benzo[a]pyrene. In all cases, if the genome is not repaired, these and other genotoxic lesions precipitate serious biological consequences, including altered gene expression, mutation, and cell death. In addition to the genotoxic responses, it is increasingly being recognized that DNA lesions can alter the epigenetic profiles that are imprinted by naturally occurring DNA modifications.

The impetus for this volume came from a recent symposium sponsored by the ACS Division of Chemical Toxicology, bringing together scientists interested in the synthesis and structures of site-specific DNA adducts and in mechanistic aspects of DNA repair. This volume presents work at the interface between the structural biology of DNA damage and DNA repair.

A propos du livre

À propos de l?auteur

Michael P. Stone is Professor & Department Chairman of the Department of Chemistry at Vanderbuilt University.

Détails de l'édition

• Éditeur: Oxford University Press Inc
• Date d'édition: 2011
• Langue: anglais
• ISBN 10: 0841225745
• ISBN 13: 9780841225749
• Reliure: Relié
• Nombre de pages: 138
• Éditeur: Stone Michael
• Coordonnées du fabricant: non disponible
• Personne responsable: Messaggerie Libri; ufficio.anagrafiche@meli.it; ; Via Verdi, 8; Assago Milano; Italie