Imagine scientists controlling the transmission of certain diseases through the genetic modification of mosquitoes. Eradicating harmful insects without the use of pesticides. Or increasing the fertility of some insects who in turn eat harmful arthropods or even a plant pathogen. Those are just a few of the real-world applications of insect transgenesis, which offers substantial benefits to humankind-whether it be in improving agricultural productivity or reducing the spread of insect-vectored diseases.
Insect Transgenesis: Methods and Applications is the first publication to describe in a comprehensive manner the various methodologies available, possible applications, and the risk assessment and regulatory issues involved in this fascinating area of research.
Divided into several areas of interest, the book starts with an overview of the history and methodology of insect gene transfer. The book then examines gene targeting by homologous recombination and recombination systems, and systems for transgenic selection, including visible eye color markers, chemical resistance, and fluorescent proteins. Other sections consider the use of various vector systems to integrate DNA into a host genome or to express foreign genes in a host organism.
The work concludes with strategies for the use of transgenic insects, including examples for agricultural pests and vectors of disease. Of particular interest are the final chapters that discuss risk assessment considerations and governmental regulatory procedures for the transport and release of transgenic insects.
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Alfred M. Handler, Ph.D., is a Research Geneticist at the USDA, ARS Center for Medical, Agricultural and Veterinary Entomology in Gainesville, Florida. Dr. Handler received his B.S. in biology from the State University of New York at Stony Brook in 1972, and his Ph.D. in biology (developmental genetics) from the University of Oregon in 1977. He held a postdoctoral fellowship in genetics at the Division of Biology, California Institute of Technology, Pasadena, from 1977 to 1979, and then joined die Developmental Biology Center at the University of California, Irvine as a research biologist from 1979 to 1985. During this time he was a visiting research associate at the Zoological Institute, University of Zürich, Switzerland and the Technische Hochschule, Darmstadt, Germany. In 1985 he joined the Agricultural Research Service in Gainesville, Florida, and in 1995 he was a visiting scientist at the Laboratory of Comparative Pathology, University of Montpellier II, France. Dr. Handler is the U.S. scientific coordinator for a cooperative scientific program between the USDA-ARS and the French Centre National Recherche Scientifiques (CNRS) on "Transgenesis of Invertebrate Organisms of Economic and Medical Importance." As part of this role he bas served as conference organizer for the "International Workshops on Transgenesis of Invertebrate Organisms." Dr. Handler bas served as a consultant and expert panel member for several international organizations in the field of insect genetics and transgenesis. Dr. Handler's research at the USDA-ARS bas centered on the use of transgenic insects for biological control programs. Most of his efforts have focused on the development of efficient gene transfer vector and marker systems. Anthony A. James, Ph.D., is Professor of Molecular Biology and Biochemistry at the University of California, Irvine (UCI). Dr. James received his B.S. in biology from UCI in 1973, and his Ph.D. in developmental biology from UCI in 1979. He held postdoctoral positions in the Department of Biological Chemistry, Harvard Medical School, and the Department of Biology, Brandeis University, before joining the faculty of the Department of Tropical Public Health at the Harvard School of Public Health in 1985. Dr. James returned to his alma mater in 1989, where he has remained. Dr. James was a principal investigator with the Network on the Biology of Parasite Vectors funded by die John D. and Catherine T. MacArthur Foundation and was a recipient of die Molecular Parasitology Award from die Burroughs-Wellcome Fund. He is a fellow of the American Association for the Advancement of Science and the Royal Entomological Society of London. He is a founding editor of Insect Molecular Biology, and is on the editorial board of Experimental Parasitology. Dr. James' areas of interest include vector-parasite interactions, mosquito molecular biology, and other problems in insect developmental biology. His current work focuses on using genetic and molecular genetic tools to interrupt parasite transmission by mosquitoes.
Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
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