This introduction to modern theories of enzyme catalysis presents the latest methods used to study quantum tunnelling in biological systems. Written in an accessible style, it is suitable for a wide audience but will be particularly useful to advanced level undergraduates, postgraduates and early postdoctoral workers. The book starts with an introduction by Nobel Laureate, Rudolph A. Marcus. The reader is then guided through computational, kinetic and structural analysis of tunnelling and the synergy in combining these methods (with a major focus on H-tunneling reactions in enzyme systems). Edited by two leading experts, and bringing together the foremost practitioners in the field, this up-to-date account of a rapidly developing field sits at the interface between biology, chemistry and physics.
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Nigel S. Scrutton graduated from King's College University of London before obtaining PhD and ScD degrees at the University of Cambridge. He is currently BBSRC Professorial Fellow and Professor of Enzymology at the University of Manchester. He has a longstanding interest in structural and mechanistic enzymology and has made a number of major contributions to the field of H-tunneling in biological systems. He has also been involved in interdisciplinary research programmes addressing the mechanisms of electron and hydrogen transfer in biology. Rudolf K. Allemann obtained a Dipl. Chem from the ETH in Zurich. He then studied for a PhD at Harvard University and the ETH-Zurich where he obtained Dr. sc. Nat. in 1988. He is currently a Research Professor and head of Chemical Biology at Cardiff University. His research interests focus on the physical and chemical basis of enzyme catalysis and structural and synthetic biology. He has also been involved in the de novo design of peptides that catalyze reactions with enzyme-like characteristics. Recently, he has pioneered the development of biophotonic nanoswitches for the control of protein-DNA and protein-protein interactions.
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