Synopsis
Written by a team of experts, this book bridges the gap between the DNA- and RNA- views of protein-nucleic acid recognition which are often treated as separate fields.
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
À propos de l'auteur
Dr Rice is an associate professor in the Department of Biochemistry & Molecular Biology at the University of Chicago. Having trained in the labs of Thomas Steitz at Yale and Kiyoshi Mizuuchi at NIH, she has a long-standing interest in the mechanisms and structural biology of DNA recombination. Dr Correll is an associate professor in the Department of Biochemistry & Molecular Biology at Rosalind Franklin University of Medicine and Science. Having trained in the labs of Profs. Martha Ludwig at the University of Michigan and Thomas Steitz at Yale University, he has a long-standing interest in structural biology. For the last decade his research has focused on how proteins cleave and/or rearrange the structure of RNA molecules.
Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
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Protein-Nucleic Acid Interactions: Structural Biology
Edité par
RSC publishing, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
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Etat : Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. Clean from markings. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,900grams, ISBN:9780854042722. N° de réf. du vendeur 9856261
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PROTEIN NUCLEIC ACID INTERACTIONS STRUCTURAL BIOLOGY (HB 2008)
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SP RSC PUBLISHING, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
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Protein-Nucleic Acid Interactions : Structural Biology
Edité par
Royal Society of Chemistry, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
Neuf
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Protein-Nucleic Acid Interactions
Edité par
Royal Society of Chemistry, GB, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
Neuf
Couverture rigide
Vendeur : Rarewaves USA, OSWEGO, IL, Etats-Unis
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Hardback. Etat : New. The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. New insights are now being gained from comparative studies only recently made possible due to the size of the database, as well as from careful biochemical and biophysical studies. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review. Instead, current review articles tend to focus on particular subtopics of interest. This makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic acid interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also aims to bridge the gap between the DNA- and the RNA- views of nucleic acid - protein recognition, which are often treated as separate fields. However, this is a false dichotomy because protein - DNA and protein - RNA interactions share many general principles. This book therefore includes relevant examples from both sides, and frames discussions of the fundamentals in terms that are relevant to both. The monograph approaches the study of protein-nucleic acid interactions in two distinctive ways. First, DNA-protein and RNA-protein interactions are presented together. Second, the first half of the book develops the principles of protein-nucleic acid recognition, whereas the second half applies these to more specialized topics. Both halves are illustrated with important real life examples. The first half of the book develops fundamental principles necessary to understand function. An introductory chapter by the editors reviews the basics of nucleic acid structure. Jen-Jacobsen and Jacobsen discuss how solvent interactions play an important role in recognition, illustrated with extensive thermodynamic data on restriction enzymes. Marmorstein and Hong introduce the zoology of the DNA binding domains found in transcription factors, and describe the combinational recognition strategies used by many multiprotein eukaryotic complexes. Two chapters discuss indirect readout of DNA sequence in detail: Berman and Lawson explain the basic principles and illustrate them with in-depth studies of CAP, while in their chapter on DNA bending and compaction Johnson, Stella and Heiss highlight the intrinsic connections between D. N° de réf. du vendeur LU-9780854042722
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Protein-Nucleic Acid Interactions
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Royal Society of Chemistry, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
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Protein-Nucleic Acid Interactions
Edité par
Royal Society of Chemistry, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
Neuf
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Protein-Nucleic Acid Interactions : Structural Biology
Edité par
Royal Society of Chemistry, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
Neuf
Couverture rigide
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Protein-Nucleic Acid Interactions: Structural Biology
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Royal Society of Chemistry, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
Neuf
Couverture rigide
Vendeur : THE SAINT BOOKSTORE, Southport, Royaume-Uni
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Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences, Volume 11)
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Royal Society of Chemistry, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
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Protein-Nucleic Acid Interactions
Edité par
Royal Society of Chemistry, GB, 2008
ISBN 10 : 0854042725
ISBN 13 : 9780854042722
Neuf
Couverture rigide
Vendeur : Rarewaves USA United, OSWEGO, IL, Etats-Unis
Évaluation du vendeur 5 sur 5 étoiles
Hardback. Etat : New. The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. New insights are now being gained from comparative studies only recently made possible due to the size of the database, as well as from careful biochemical and biophysical studies. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review. Instead, current review articles tend to focus on particular subtopics of interest. This makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic acid interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also aims to bridge the gap between the DNA- and the RNA- views of nucleic acid - protein recognition, which are often treated as separate fields. However, this is a false dichotomy because protein - DNA and protein - RNA interactions share many general principles. This book therefore includes relevant examples from both sides, and frames discussions of the fundamentals in terms that are relevant to both. The monograph approaches the study of protein-nucleic acid interactions in two distinctive ways. First, DNA-protein and RNA-protein interactions are presented together. Second, the first half of the book develops the principles of protein-nucleic acid recognition, whereas the second half applies these to more specialized topics. Both halves are illustrated with important real life examples. The first half of the book develops fundamental principles necessary to understand function. An introductory chapter by the editors reviews the basics of nucleic acid structure. Jen-Jacobsen and Jacobsen discuss how solvent interactions play an important role in recognition, illustrated with extensive thermodynamic data on restriction enzymes. Marmorstein and Hong introduce the zoology of the DNA binding domains found in transcription factors, and describe the combinational recognition strategies used by many multiprotein eukaryotic complexes. Two chapters discuss indirect readout of DNA sequence in detail: Berman and Lawson explain the basic principles and illustrate them with in-depth studies of CAP, while in their chapter on DNA bending and compaction Johnson, Stella and Heiss highlight the intrinsic connections between D. N° de réf. du vendeur LU-9780854042722
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