A collection of methods to determine and analyse the 3-D structure of biomolecules. These methods have been enhanced to improve the speed and quality of drug discovery.
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
War is invariably accompanied by debate, if not controversy, over the legitimacy of using force. Alongside the longstanding state practice of justifying use of force is the increasing codification of legal rules on the use of force. In this volume a leading group of international authorities consider the issues surrounding the legitimation of force from several distinct disciplinary perspectives, including political science, law, history and philosophy. In particular, they examine the underlying question of whether and how international society's traditional norms of sovereignty and non-intervention can coexist both with the new norm of humanitarian intervention and with an increasingly hegemonial (if not 'imperial') role played by the United States. What is the difference between 'legality' and 'legitimacy'? Is the latter a truly universal concept or mainly a Western one? Are earlier ideas about 'just war' still relevant?
David Armstrong is Professor of International Relations, Department of Politics, University of Exeter.
Theo Farrell is Reader in War in the Modern World, Department of War Studies, King's College London.
Bice Maiguashca is Lecturer in Politics, Department of Politics, University of Exeter.
Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
Vendeur : Basi6 International, Irving, TX, Etats-Unis
Etat : Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service. N° de réf. du vendeur ABEOCT25-129516
Quantité disponible : 1 disponible(s)
Vendeur : Romtrade Corp., STERLING HEIGHTS, MI, Etats-Unis
Etat : New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide. N° de réf. du vendeur ABBB-59770
Quantité disponible : 2 disponible(s)
Vendeur : SMASS Sellers, IRVING, TX, Etats-Unis
Etat : New. Brand New Original US Edition. Customer service! Satisfaction Guaranteed. N° de réf. du vendeur SNTA-59770
Quantité disponible : 2 disponible(s)
Vendeur : Romtrade Corp., STERLING HEIGHTS, MI, Etats-Unis
Etat : New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide. N° de réf. du vendeur ABBB-203220
Quantité disponible : 2 disponible(s)
Vendeur : Basi6 International, Irving, TX, Etats-Unis
Etat : Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service. N° de réf. du vendeur ABEOCT25-129517
Quantité disponible : 8 disponible(s)
Vendeur : SMASS Sellers, IRVING, TX, Etats-Unis
Etat : New. Brand New Original US Edition. Customer service! Satisfaction Guaranteed. N° de réf. du vendeur SNTA-203220
Quantité disponible : 2 disponible(s)
Vendeur : Books Puddle, New York, NY, Etats-Unis
Etat : New. pp. 278. N° de réf. du vendeur 26300241
Quantité disponible : 1 disponible(s)
Vendeur : Majestic Books, Hounslow, Royaume-Uni
Etat : New. pp. 278 Illus. N° de réf. du vendeur 7547662
Quantité disponible : 1 disponible(s)
Vendeur : Studibuch, Stuttgart, Allemagne
hardcover. Etat : Sehr gut. 278 Seiten; 9780854043514.2 Gewicht in Gramm: 500. N° de réf. du vendeur 1286110
Quantité disponible : 1 disponible(s)
Vendeur : Rarewaves USA, OSWEGO, IL, Etats-Unis
Hardback. Etat : New. Structure-based drug discovery is a collection of methods that exploits the ability to determine and analyse the three dimensional structure of biological molecules. These methods have been adopted and enhanced to improve the speed and quality of discovery of new drug candidates. After an introductory overview of the principles and application of structure-based methods in drug discovery, this book then describes the essential features of the various methods. Chapters on X-ray crystallography, NMR spectroscopy, and computational chemistry and molecular modelling describe how these particular techniques have been enhanced to support rational drug discovery, with discussions on developments such as high throughput structure determination, probing protein-ligand interactions by NMR spectroscopy, virtual screening and fragment-based drug discovery. The concluding chapters complement the overview of methods by presenting case histories to demonstrate the major impact that structure-based methods have had on discovering drug molecules. Written by international experts from industry and academia, this comprehensive introduction to the methods and practice of structure-based drug discovery not only illustrates leading-edge science but also provides the scientific background for the non-expert reader. The book provides a balanced appraisal of what structure-based methods can and cannot contribute to drug discovery. It will appeal to industrial and academic researchers in pharmaceutical sciences, medicinal chemistry and chemical biology, as well as providing an insight into the field for recent graduates in the biomolecular sciences. N° de réf. du vendeur LU-9780854043514
Quantité disponible : Plus de 20 disponibles