The p53 Family: A Subject Collection from Cold Spring Harbor Perspectives in Biology - Couverture rigide

 
9780879698300: The p53 Family: A Subject Collection from Cold Spring Harbor Perspectives in Biology

Synopsis

The p53 tumor suppressor gene the guardian of the genome protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of transcription factors (p53, p63, and p73) that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.

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Présentation de l'éditeur

The p53 tumor suppressor gene the guardian of the genome protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of transcription factors (p53, p63, and p73) that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.

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