Articles liés à Means to an End: Apoptosis and Other Cell Death Mechanisms
Synopsis
Apoptosis (programmed cell death) plays a critical role in development, normal physiology, and many diseases, including cancer. Apoptosis researchers form a distinct research community but investigators in many areas of cell, developmental, and molecular biology, as well as immunology and neurobiology, also study the process. This short book describes our detailed understanding of the mechanisms involved in apoptotic signaling and execution, covering signal transducers, caspases, BCL-2family proteins, mitochondrial molecules, and IAPs. It also critically discusses key questions that remain in the field, for example, whether caspases are always necessary, the distinction between the intrinsic and extrinsic pathways of apoptosis, and the role of mitochondria, that are often glossed over or ignored elsewhere.
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Présentation de l'éditeur
Apoptosis (programmed cell death) plays a critical role in development, normal physiology, and many diseases, including cancer. Apoptosis researchers form a distinct research community but investigators in many areas of cell, developmental, and molecular biology, as well as immunology and neurobiology, also study the process. This short book describes our detailed understanding of the mechanisms involved in apoptotic signaling and execution, covering signal transducers, caspases, BCL-2family proteins, mitochondrial molecules, and IAPs. It also critically discusses key questions that remain in the field, for example, whether caspases are always necessary, the distinction between the intrinsic and extrinsic pathways of apoptosis, and the role of mitochondria, that are often glossed over or ignored elsewhere.
Revue de presse
Green (St Jude Children s Research Hospital) provides a comprehensive look at the current understanding of the multilayered processes by which cells in the body die...Means to an End is a complex but improbably thrilling read that manages to convey not only the hard work associated with cell biology but also the joy of its eureka moments. --Choice
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Means to an End: Apoptosis and Other Cell Death Mechanisms
Edité par
Cold Spring Harbor Laboratory Press, 2010
ISBN 10 : 087969887X
ISBN 13 : 9780879698874
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Etat : good. Pages are clean with normal wear. May have limited markings & or highlighting within pages & or cover. Includes dustjacket, if applicable. May have some wear & creases on the cover. The spine may also have minor wear. Does not come with CD DVD, if applicable. Access code has been used, if applicable. Does not come with any supplementary materials. N° de réf. du vendeur VLM.OA
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Means to an End: Apoptosis and Other Cell Death Mechanisms
Edité par
Cold Spring Harbor Laboratory Pr, 2010
ISBN 10 : 087969887X
ISBN 13 : 9780879698874
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Hardcover. Etat : Brand New. 1st edition. 250 pages. 9.00x6.75x0.75 inches. In Stock. N° de réf. du vendeur __087969887X
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Means to an End
Edité par
Cold Spring Harbor Laboratory Press,U.S., US, 2010
ISBN 10 : 087969887X
ISBN 13 : 9780879698874
Neuf
Couverture rigide
Vendeur : Rarewaves.com USA, London, LONDO, Royaume-Uni
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Means to an End: Apoptosis and Other Cell Death Mechanisms
Edité par
COLD SPRING HARBOR LABORATORY, 2010
ISBN 10 : 087969887X
ISBN 13 : 9780879698874
Neuf
Couverture rigide
Vendeur : moluna, Greven, Allemagne
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Gebunden. Etat : New. KlappentextOne million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and . N° de réf. du vendeur 595123104
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Means to an End : Apoptosis and Other Cell Death Mechanisms
Edité par
Cold Spring Harbor Laboratory Press Dez 2010, 2010
ISBN 10 : 087969887X
ISBN 13 : 9780879698874
Neuf
Couverture rigide
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
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Buch. Etat : Neu. Neuware - One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field. N° de réf. du vendeur 9780879698874
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Means to an End
Edité par
Cold Spring Harbor Laboratory Press,U.S., US, 2010
ISBN 10 : 087969887X
ISBN 13 : 9780879698874
Neuf
Couverture rigide
Vendeur : Rarewaves.com UK, London, Royaume-Uni
Évaluation du vendeur 5 sur 5 étoiles
Hardback. Etat : New. N° de réf. du vendeur LU-9780879698874
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Means to an End: Apoptosis and Other Cell Death Mechanisms
Edité par
Cold Spring Harbor Laboratory, 2010
ISBN 10 : 087969887X
ISBN 13 : 9780879698874
Ancien ou d'occasion
Couverture rigide
Vendeur : CSG Onlinebuch GMBH, Darmstadt, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Gebundene Ausgabe. Etat : Wie neu. Gebraucht - Wie neu -One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field. N° de réf. du vendeur 43313
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