Means to an End: Apoptosis and Other Cell Death Mechanisms - Couverture souple

 
9780879698881: Means to an End: Apoptosis and Other Cell Death Mechanisms

Synopsis

Apoptosis (programmed cell death) plays a critical role in development, normal physiology, and many diseases, including cancer. Apoptosis researchers form a distinct research community but investigators in many areas of cell, developmental, and molecular biology, as well as immunology and neurobiology, also study the process. This short book describes our detailed understanding of the mechanisms involved in apoptotic signaling and execution, covering signal transducers, caspases, BCL-2family proteins, mitochondrial molecules, and IAPs. It also critically discusses key questions that remain in the field, for example, whether caspases are always necessary, the distinction between the intrinsic and extrinsic pathways of apoptosis, and the role of mitochondria, that are often glossed over or ignored elsewhere.

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Présentation de l'éditeur

Apoptosis (programmed cell death) plays a critical role in development, normal physiology, and many diseases, including cancer. Apoptosis researchers form a distinct research community but investigators in many areas of cell, developmental, and molecular biology, as well as immunology and neurobiology, also study the process. This short book describes our detailed understanding of the mechanisms involved in apoptotic signaling and execution, covering signal transducers, caspases, BCL-2family proteins, mitochondrial molecules, and IAPs. It also critically discusses key questions that remain in the field, for example, whether caspases are always necessary, the distinction between the intrinsic and extrinsic pathways of apoptosis, and the role of mitochondria, that are often glossed over or ignored elsewhere.

Revue de presse

Green (St Jude Children s Research Hospital) provides a comprehensive look at the current understanding of the multilayered processes by which cells in the body die...Means to an End is a complex but improbably thrilling read that manages to convey not only the hard work associated with cell biology but also the joy of its eureka moments. --Choice

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Autres éditions populaires du même titre

9780879698874: Means to an End: Apoptosis and Other Cell Death Mechanisms

Edition présentée

ISBN 10 :  087969887X ISBN 13 :  9780879698874
Editeur : Cold Spring Harbor Laboratory Pr..., 2010
Couverture rigide