Apoptosis (programmed cell death) plays a critical role in development, normal physiology, and many diseases, including cancer. Apoptosis researchers form a distinct research community but investigators in many areas of cell, developmental, and molecular biology, as well as immunology and neurobiology, also study the process. This short book describes our detailed understanding of the mechanisms involved in apoptotic signaling and execution, covering signal transducers, caspases, BCL-2family proteins, mitochondrial molecules, and IAPs. It also critically discusses key questions that remain in the field, for example, whether caspases are always necessary, the distinction between the intrinsic and extrinsic pathways of apoptosis, and the role of mitochondria, that are often glossed over or ignored elsewhere.
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Apoptosis (programmed cell death) plays a critical role in development, normal physiology, and many diseases, including cancer. Apoptosis researchers form a distinct research community but investigators in many areas of cell, developmental, and molecular biology, as well as immunology and neurobiology, also study the process. This short book describes our detailed understanding of the mechanisms involved in apoptotic signaling and execution, covering signal transducers, caspases, BCL-2family proteins, mitochondrial molecules, and IAPs. It also critically discusses key questions that remain in the field, for example, whether caspases are always necessary, the distinction between the intrinsic and extrinsic pathways of apoptosis, and the role of mitochondria, that are often glossed over or ignored elsewhere.
Green (St Jude Children s Research Hospital) provides a comprehensive look at the current understanding of the multilayered processes by which cells in the body die...Means to an End is a complex but improbably thrilling read that manages to convey not only the hard work associated with cell biology but also the joy of its eureka moments. --Choice
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Vendeur : ThriftBooks-Dallas, Dallas, TX, Etats-Unis
Paperback. Etat : Very Good. No Jacket. May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend Less. N° de réf. du vendeur G0879698888I4N00
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Vendeur : Books From California, Simi Valley, CA, Etats-Unis
paperback. Etat : Fine. N° de réf. du vendeur mon0003782754
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Vendeur : Phatpocket Limited, Waltham Abbey, HERTS, Royaume-Uni
Etat : Good. Your purchase helps support Sri Lankan Children's Charity 'The Rainbow Centre'. Ex-library, so some stamps and wear, but in good overall condition. Our donations to The Rainbow Centre have helped provide an education and a safe haven to hundreds of children who live in appalling conditions. N° de réf. du vendeur Z1-C-076-04828
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Vendeur : Books From California, Simi Valley, CA, Etats-Unis
paperback. Etat : New. N° de réf. du vendeur mon0003780924
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Vendeur : Anybook.com, Lincoln, Royaume-Uni
Etat : Fair. This is an ex-library book and may have the usual library/used-book markings inside.This book has soft covers. In fair condition, suitable as a study copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,500grams, ISBN:9780879698881. N° de réf. du vendeur 9981551
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Vendeur : GreatBookPrices, Columbia, MD, Etats-Unis
Etat : As New. Unread book in perfect condition. N° de réf. du vendeur 11868896
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Vendeur : GreatBookPricesUK, Woodford Green, Royaume-Uni
Etat : New. N° de réf. du vendeur 11868896-n
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Vendeur : GreatBookPricesUK, Woodford Green, Royaume-Uni
Etat : As New. Unread book in perfect condition. N° de réf. du vendeur 11868896
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Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -One million cells in our bodies die every secondthey commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field. 220 pp. Englisch. N° de réf. du vendeur 9780879698881
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Vendeur : Books Puddle, Woodside, NY, Etats-Unis
Etat : New. pp. 220 Index 1st Edition. N° de réf. du vendeur 262215789
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