NF-kB: A Network Hub Controlling Immunity, Inflammation, and Cancer - Couverture rigide

Karin, Michael

Couverture rigide

ISBN 10 : 0879699027 ISBN 13 : 9780879699024

Editeur : Cold Spring Harbor Laboratory Press,U.S., 2010

Synopsis

NF-kB is a critical signaling molee in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-?B, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molear biologists, immunologists, and pathologists interested in regulation of cell function.

Détails de l'édition

• Éditeur: Cold Spring Harbor Laboratory Press,U.S.
• Date d'édition: 2010
• Langue: anglais
• ISBN 10: 0879699027
• ISBN 13: 9780879699024
• Reliure: Relié
• Nombre de pages: 271
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible