G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders - Couverture rigide

Couverture rigide

ISBN 10 : 0896034909 ISBN 13 : 9780896034907

Editeur : Humana Press Inc., 1997

Synopsis

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G, G, G, and G12.

Détails de l'édition

• Éditeur: Humana Press Inc.
• Date d'édition: 1997
• Langue: anglais
• ISBN 10: 0896034909
• ISBN 13: 9780896034907
• Reliure: Relié
• Nombre de pages: 433
• Éditeur: Mishra Ram K., Baker Glen B., Boulton Alan A.
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible