Posttranslational Modification of Proteins: Tools for Functional Proteomics - Couverture rigide

Couverture rigide

ISBN 10 : 0896036782 ISBN 13 : 9780896036789

Editeur : Humana Press Inc., 2002

Synopsis

Posttranslational Modifications of Proteins: Tools for Functional Proteomics is a compilation of detailed protocols needed to detect and analyze the most important co- and posttranslational modifications of proteins. Though, for reasons of simplicity not explicitly mentioned in the title, both kinds of modifications are covered, whether they occur during, or after, biosynthesis of the protein. My intention was to cover the most significant protein modifications, focusing on the fields of protein function, proteome research, and the characterization of pharmaceutical proteins. The majority of all proteins undergo co- and/or posttranslational modifications. Knowledge of these modifications is extremely important, since they may alter physical and chemical properties, folding, conformation distribution, stability, act- ity, and, consequently, function of the proteins. Moreover, the modification itself can act as an added functional group. Examples of the biological effects of protein mo- fications include: phosphorylation for signal transduction, ubiquitination for p- teolysis, attachment of fatty acids for membrane anchoring or association, glycosylation for protein half-life, targeting, cell-cell and cell-matrix interactions, and carboxylation in protein-ligand binding to name just a few. Full understanding of a specific protein structure-function relationship requires detailed information not only on its amino acid sequence, which is determined by the corresponding DNA sequence, but also on the presence and structure of protein modifications.

Détails de l'édition

• Éditeur: Humana Press Inc.
• Date d'édition: 2002
• Langue: anglais
• ISBN 10: 0896036782
• ISBN 13: 9780896036789
• Reliure: Relié
• Nombre de pages: 333
• Éditeur: Kannicht Christoph
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible