Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.
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This volume details the latest information on the production and analysis of transgenic and knockout mice. It explores advances in the field through laboratory protocols. Each chapter features an introduction, step-by-step methods and a list of materials.
Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
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