Novel Anticancer Drug Protocols - Couverture rigide

Couverture rigide

ISBN 10 : 0896039633 ISBN 13 : 9780896039636

Editeur : Humana Press Inc., 2003

Synopsis

We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin(R) (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia.

Détails de l'édition

• Éditeur: Humana Press Inc.
• Date d'édition: 2003
• Langue: anglais
• ISBN 10: 0896039633
• ISBN 13: 9780896039636
• Reliure: Relié
• Nombre de pages: 371
• Éditeur: Buolamwini John K., Adjei Alex A.
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne