Drug Stereochemistry: Analytical Methods and Pharmacology - Couverture souple

Couverture souple

ISBN 10 : 1032921889 ISBN 13 : 9781032921884

Editeur : CRC Press, 2024

Synopsis

Drug Stereochemistry: Analytical Methods and Pharmacology, Third Edition covers all aspects of chiral drugs from academic, governmental, industrial, and clinical perspectives, reflecting the many advances in techniques and methodology.

Topics include:

• The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery
• How stereochemistry impacts decisions made in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) stages of drug discovery
• Pharmacokinetics and pharmacodynamics and the issues faced during the final stages of the drug development process
• The impact of the International Conference on Harmonisation (ICH) on the use of single isomer drugs
• Chiral switches
• The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs
• Patent issues surrounding chiral switches and the marketing of single enantiomer switches

The book provides a solid background on stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. It is a one-stop reference for pharmaceutical scientists and chemists working with chiral drug molecules.

A propos du livre

À propos de l'auteur

Professor Krzysztof Józwiak is head of laboratory of medicinal chemistry and neuroengineering of Medical University of Lublin, Poland

Dr W John Lough is reader in pharmaceutical analysis in the Department of Pharmacy, Health and Well-Being at the University of Sunderland, UK

Irving W. Wainer, Ph.D. is senior investigator, in the Bioanalytical Chemistry and Drug Discovery Section, Laboratory for Clinical Investigation, National Institute of Aging/National Institutes of Health

Détails de l'édition

• Éditeur: CRC Press
• Date d'édition: 2024
• Langue: anglais
• ISBN 10: 1032921889
• ISBN 13: 9781032921884
• Reliure: Broché
• Numéro d'édition: 3
• Nombre de pages: 330
• Éditeur: Jozwiak Krzysztof, Lough W. J., Wainer Irving W.
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible