Systems Biology: Constraint-based Reconstruction and Analysis - Couverture rigide

Palsson, Bernhard Ø.

Couverture rigide

ISBN 10 : 1107038855 ISBN 13 : 9781107038851

Editeur : Cambridge University Press, 2015

Synopsis

Recent technological advances have enabled comprehensive determination of the molecular composition of living cells. The chemical interactions between many of these molecules are known, giving rise to genome-scale reconstructed biochemical reaction networks underlying cellular functions. Mathematical descriptions of the totality of these chemical interactions lead to genome-scale models that allow the computation of physiological functions. Reflecting these recent developments, this textbook explains how such quantitative and computable genotype-phenotype relationships are built using a genome-wide basis of information about the gene portfolio of a target organism. It describes how biological knowledge is assembled to reconstruct biochemical reaction networks, the formulation of computational models of biological functions, and how these models can be used to address key biological questions and enable predictive biology. Developed through extensive classroom use, the book is designed to provide students with a solid conceptual framework and an invaluable set of modeling tools and computational approaches.

A propos du livre

À propos de l?auteur

Bernhard O. Palsson is the Galletti Professor of Bioengineering and Professor of Pediatrics at the University of California, San Diego. For almost 30 years, his research has focused on the development of large-scale models of biological functions and their use to solve basic and applied problems in the life sciences. He has authored three previous textbooks.

Détails de l'édition

• Éditeur: Cambridge University Press
• Date d'édition: 2015
• Langue: anglais
• ISBN 10: 1107038855
• ISBN 13: 9781107038851
• Reliure: Relié
• Nombre de pages: 550
• Coordonnées du fabricant: Cambridge University Press; https://www.cambridge.org/; ; Via Honduras,15; Pomezia; Italia; 71; Italie