Synopsis
This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
À propos de l?auteur
Fiorenzo Stirpe is Professor Emeritus at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
Douglas A. Lappi is the President and Chief Scientific Officer of Advanced Targeting Systems, USA.
Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
Résultats de recherche pour Ribosome-Inactivating Proteins: Ricin and Related Proteins
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Ribosome-inactivating Proteins: Ricin and Related Proteins
Edité par
Wiley-Blackwell, 2014
ISBN 10 : 1118125657
ISBN 13 : 9781118125656
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Vendeur : Great Matter Books, Grand Rapids, MI, Etats-Unis
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Hardcover. Etat : Very Good. No Jacket. Very Good condition hardcover book, no dust jacket. Shelf wear to covers. Bumping to spine ends. Pages lightly toned and smudged at text block edges and margins, pages are otherwise clean and unmarked. All books are individually inspected and described. Never X-Library unless specifically described as such. N° de réf. du vendeur 2511-2600
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Ribosome-inactivating Proteins: Ricin and Related Proteins
Edité par
Wiley-Blackwell, 2014
ISBN 10 : 1118125657
ISBN 13 : 9781118125656
Ancien ou d'occasion
Couverture rigide
Vendeur : Flamingo Books, Menifee, CA, Etats-Unis
Évaluation du vendeur 5 sur 5 étoiles
hardcover. Etat : Very Good. 2014 signed and inscribed first edition, association copy (1977 Nobel winner Roger Guillemin), 7 x 9 7/8 inches tall color pictorial hardcover, no dust jacket (as issued), illustrated with color and black-and-white diagrams and drawings, index, xii, 296 pp. Laid in is a slip reading, 'From the Private Colllection of Dr. Roger and Lucienne Guillemin, Nobel Laureate, 1977, Salk Institute, La Jolla, CA.' Roger Charles Louis Guillemin (1924-2024) was a French-American neuroscientist who received the National Medal of Science in 1976, and the Nobel Prize for Medicine in 1977 for his work on neurohormones. Very slight soiling, rubbing and edgewear to covers. On the title page, nicely signed by author Douglas Lappi and inscribed to Guillemin, widely considered the 'father of neuroendocrinology' and winner of the Nobel prize for medicine. Otherwise, a very good to near fine copy - clean, bright and unmarked. ~SP19~ [2.5P] This important reference provides information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain. Contents: Preface; 1 Introduction and History; Introduction; Identification and Distribution in Nature; Mechanism of Action; Effects on Cells and Animals; Role in Nature; Practical Applications; Bioweapons; Future Challenges; References; 2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily; Introduction; How to Investigate the Distribution of Proteins with an N-glycosidase Domain?; Conclusions; Acknowledgments. IntroductionFamily Sambuceae; Type 2 RIPs from Other families; Uses of nontoxic type 2 RIPs; Concluding remarks; Acknowledgment; References; 6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins; Introduction; Cell Surface Events; Endosome to TGN Sorting; From the Golgi to the ER; Reductive Separation and Destabilization of the Holotoxin Subunits; Dislocation Across the ERâ?0 embrane; Cytosolic Post-dislocation Events that Restore Catalytic Activity; Concluding Remarks; Acknowledgements; References. 7 Shiga ToxinsIntroduction; Purification of Shiga Toxins; Structure and Mechanism of Action of Shiga Toxins; Role of Shiga Toxins in the Pathogenesis of HUS; The 2011 German STEC Outbreak; References; 8 The Structure and Action of Ribosome-inactivating Proteins; Introduction; Acknowledgments; References; 9 Updated Model of the Molecular Evolution of RIP Genes; Introduction; Important Issues to be Considered in View of the Evolution of RIP Genes. Dissecting RIP Genes and RIP Gene Families by in silico Analysis of Genome and Transcriptome DataNew Insights in the Overall Phylogeny of Plant RIPs; An Updated Model of the Molecular Evolution of the Plant RIP Gene Family; What is the Evolutionary Link Between Plant and Non-Plant RIPs?; Conclusions; References; 10 Enzymology of the Ribosome-inactivating Proteins; Introduction; Ricin as RNA N-glycosidase; Role of SRL in Ribosomes; Ribosomal RNA Apurinic Site-specific Lyase Intrinsic Stability of the Ribosomes; Action of RIPs on DNA. N° de réf. du vendeur SP19-0352-14828
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Ribosome-Inactivating Proteins : Ricin and Related Proteins
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Etat : New. N° de réf. du vendeur 12471934-n
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Ribosome-inactivating Proteins Format: Hardcover
Edité par
John Wiley and Sons, 2014
ISBN 10 : 1118125657
ISBN 13 : 9781118125656
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Vendeur : INDOO, Avenel, NJ, Etats-Unis
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Ribosome-Inactivating Proteins : Ricin and Related Proteins
Edité par
Wiley-Blackwell, 2014
ISBN 10 : 1118125657
ISBN 13 : 9781118125656
Ancien ou d'occasion
Couverture rigide
Vendeur : GreatBookPrices, Columbia, MD, Etats-Unis
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Etat : As New. Unread book in perfect condition. N° de réf. du vendeur 12471934
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Ribosome-Inactivating Proteins
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Ribosome-inactivating Proteins (Hardcover)
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John Wiley and Sons Ltd, Hoboken, 2014
ISBN 10 : 1118125657
ISBN 13 : 9781118125656
Neuf
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Vendeur : Grand Eagle Retail, Bensenville, IL, Etats-Unis
Évaluation du vendeur 5 sur 5 étoiles
Hardcover. Etat : new. Hardcover. This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain. This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Shipping may be from multiple locations in the US or from the UK, depending on stock availability. N° de réf. du vendeur 9781118125656
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Ribosome-Inactivating Proteins : Ricin and Related Proteins
Edité par
Wiley-Blackwell, 2014
ISBN 10 : 1118125657
ISBN 13 : 9781118125656
Ancien ou d'occasion
Couverture rigide
Vendeur : GreatBookPricesUK, Woodford Green, Royaume-Uni
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Etat : As New. Unread book in perfect condition. N° de réf. du vendeur 12471934
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Ribosome-Inactivating Proteins : Ricin and Related Proteins
Vendeur : GreatBookPricesUK, Woodford Green, Royaume-Uni
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Etat : New. N° de réf. du vendeur 12471934-n
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Ribosome-inactivating Proteins: Ricin and Related Proteins
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