Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development - Couverture rigide

Livre 6 sur 9: Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods

El-Kattan, Ayman F.

 
9781118916698: Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development
Couverture rigide
ISBN 10 : 1118916697 ISBN 13 : 9781118916698
Editeur : John Wiley & Sons Inc, 2017

Synopsis

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.

- Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
- Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
- Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
- Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
- Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l?auteur

AYMAN F. EL-KATTAN, B. Pharm, PhD, is Associate Research Fellow in Pfizer's Pharmacokinetics, Dynamics, and Metabolism Department, Cambridge Laboratories and an Adjunct Professor at College of Pharmacy-University of Rhode Island in Rhode Island, US. Dr. El-Kattan is a reviewer for several journals and is an active member of the American Association of Pharmaceutical Scientists (AAPS). He serves on the executive committee of the Drug Transporter focus group. He has been invited speaker 50 times at national/international conferences and has published over 100 papers in peer-reviewed Journals, book chapters, and proceedings.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
John Wiley & Sons Inc
Date d'édition
2017
Langue
anglais
ISBN 10 
1118916697
ISBN 13 
9781118916698
Reliure
Relié
Numéro d'édition
1
Nombre de pages
448
Coordonnées du fabricant
non disponible
Personne responsable
non disponible