Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R - Couverture rigide

Livre 90 sur 155: Chapman & Hall/CRC Biostatistics

Wu, Jianrong

 
9781138033221: Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R
Couverture rigide
ISBN 10 : 1138033227 ISBN 13 : 9781138033221
Editeur : CRC Press, 2018

Synopsis

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or proportional hazards model. In practice, however, those model assumptions may not be satisfied for long-term survival trials.

This book is the first to cover comprehensively the many newly developed methodologies for survival trial design, including trial design under the Weibull survival models; extensions of the sample size calculations under the proportional hazard models; and trial design under mixture cure models, complex survival models, Cox regression models, and competing-risk models. A general sequential procedure based on the sequential conditional probability ratio test is also implemented for survival trial monitoring. All methodologies are presented with sufficient detail for interested researchers or graduate students.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l?auteur

Jianrong (John) Wu is a professor in the Division of Cancer Biostatistics, Department of Biostatistics, Markey Cancer Center, University of Kentucky. He has more than 15 years' experience of designing and conducting cancer clinical trials at St. Jude Children's Research Hospital and has developed several novel statistical methods for designing phase II and phase III survival trials.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
CRC Press
Date d'édition
2018
Langue
anglais
ISBN 10 
1138033227
ISBN 13 
9781138033221
Reliure
Relié
Numéro d'édition
1
Nombre de pages
257
Coordonnées du fabricant
non disponible
Personne responsable
gpsr@libri.de
gpsr@libri.de

Friedensallee 273
Hamburg
22763
Allemagne

Autres éditions populaires du même titre

9780367734329: Statistical Methods for Survival Trial Design

Edition présentée

ISBN 10 :  036773432X ISBN 13 :  9780367734329
Editeur : Routledge, 2020
Couverture souple