Design and Analysis of Clinical Trials with Time-to-Event Endpoints - Couverture souple

9781138372665: Design and Analysis of Clinical Trials with Time-to-Event Endpoints

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ISBN 10 : 1138372668 ISBN 13 : 9781138372665

Editeur : Routledge, 2018

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This resource provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest. Incorporating the collaborations of truly world-class statisticians, it discusses the design and monitoring of Phase II and III clinical trials with time-to-event endpoints. The book presents parametric, semiparametric, categorical, and Bayesian inferential and descriptive methods for analyzing time-to-event endpoints and covers numerous clinical trial applications, including analgesic, antibiotic, antiviral, cancer and cardiovascular prevention, optimal assignment of treatments, adverse events, and carcinogenicity.

Les informations fournies dans la section � Synopsis � peuvent faire r�f�rence � une autre �dition de ce titre.

� propos de l?auteur

Karl E. Peace is Georgia Cancer Coalition Distinguished Cancer Scholar (GCCDCS), Senior Research Scientist, and Professor of Biostatistics in the Jiann-Ping Hsu College of Public Health (JPHCOPH) at Georgia Southern University. In addition to his many endowments and awards, Dr. Peace has made critical contributions to the development and approval of drugs to treat Alzheimer's disease, prevent gastrointestinal ulcers, reduce the risk of myocardial infarction, and treat anxiety/depression.

Les informations fournies dans la section � A propos du livre � peuvent faire r�f�rence � une autre �dition de ce titre.

�diteur: Routledge
Date d'�dition: 2018
Langue: anglais
ISBN 10: 1138372668
ISBN 13: 9781138372665
Reliure: Broch�
Nombre de pages: 616
�diteur: Peace Karl E.
Coordonn�es du fabricant: non disponible
Personne responsable: non disponible

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9781420066395: Design and Analysis of Clinical Trials With Time-to-Event Endpoints

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ISBN 10 : 1420066390 ISBN 13 : 9781420066395
Editeur : Chapman & Hall/CRC, 2009
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Design and Analysis of Clinical Trials With Time-to-event Endpoints

Peace, Karl E. (EDT)

Edit� par Routledge, 2018

ISBN 10 : 1138372668 ISBN 13 : 9781138372665

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Design and Analysis of Clinical Trials with Time-to-Event Endpoints

Karl E. Peace

Edit� par CRC Press, 2018

ISBN 10 : 1138372668 ISBN 13 : 9781138372665

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Design and Analysis of Clinical Trials with Time-to-Event Endpoints

Karl E. Peace

Edit� par CRC Press, 2018

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Design and Analysis of Clinical Trials with Time-to-Event Endpoints (Paperback)

Karl E. Peace

Edit� par Taylor & Francis Ltd, London, 2018

ISBN 10 : 1138372668 ISBN 13 : 9781138372665

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Paperback. Etat : new. Paperback. Using time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or "noninformativeness" of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with Time-to-Event Endpoints provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest.After reviewing time-to-event endpoint methodology, clinical trial issues, and the design and monitoring of clinical trials, the book focuses on inferential analysis methods, including parametric, semiparametric, categorical, and Bayesian methods; an alternative to the Cox model for small samples; and estimation and testing for change in hazard. It then presents descriptive and graphical methods useful in the analysis of time-to-event endpoints. The next several chapters explore a variety of clinical trials, from analgesic, antibiotic, and antiviral trials to cardiovascular and cancer prevention, prostate cancer, astrocytoma brain tumor, and chronic myelogonous leukemia trials. The book then covers areas of drug development, medical practice, and safety assessment. It concludes with the design and analysis of clinical trials of animals required by the FDA for new drug applications.Drawing on the expert contributors experiences working in biomedical research and clinical drug development, this comprehensive resource covers an array of time-to-event methods and explores an assortment of real-world applications. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. N� de r�f. du vendeur 9781138372665

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