Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling - Couverture souple

Vermillion, Rick E

 
9781288368808: Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling
Couverture souple
ISBN 10 : 1288368801 ISBN 13 : 9781288368808
Editeur : BiblioBazaar, LLC, 2012

Synopsis

A physiologically - based pharmacokinetic model has been developed to examine the effects of organophosphates on the levels of acetylcholine in different tissues throughout the mammalian body. Many organophosphate-like chemical and kinetic characteristics are tested without reference to a specific chemical. Characteristics include partition coefficients, metabolic constants, the inhibition coefficient, the aging rate, and the regeneration rate. Two separate exposure scenarios are tested and compared against a baseline. The baseline consists of a direct inhalation exposure. The first exposure scenario examines the effects of bronchial scrubbing (via inhalation) and the second scenario is a study of dermal exposures and compares the levels of ACh in the different tissues with those in the inhalation (baseline) tests. Organophosphates that are absorbed directly into the bronchial tissue exhibit little variation on the levels of ACh buildup in any of the tissue groups tested when compared to the inhalation exposures. No matter what the scrubbing coefficient used, or the combination of the parameters (partition coefficients, inhibition coefficient, aging rate, and regeneration rate) values, the change in ACh was minimal. The results showed different behavior between inhalation and dermal exposures. The dermal results suggest that an individual may have additional time to don protective equipment before the levels of ACh are high enough to render the person incapable of doing so.

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Éditeur
BiblioBazaar, LLC
Date d'édition
2012
Langue
anglais
ISBN 10 
1288368801
ISBN 13 
9781288368808
Reliure
Broché
Nombre de pages
214
Coordonnées du fabricant
non disponible
Personne responsable
gpsr@libri.de
gpsr@libri.de

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