Bayesian Modeling in Bioinformatics - Couverture rigide

Couverture rigide

ISBN 10 : 1420070177 ISBN 13 : 9781420070170

Editeur : Chapman & Hall/CRC, 2010

Synopsis

Bayesian Modeling in Bioinformatics discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research, such as cancer. It presents a broad overview of statistical inference, clustering, and classification problems in two main high-throughput platforms: microarray gene expression and phylogenic analysis.

The book explores Bayesian techniques and models for detecting differentially expressed genes, classifying differential gene expression, and identifying biomarkers. It develops novel Bayesian nonparametric approaches for bioinformatics problems, measurement error and survival models for cDNA microarrays, a Bayesian hidden Markov modeling approach for CGH array data, Bayesian approaches for phylogenic analysis, sparsity priors for protein-protein interaction predictions, and Bayesian networks for gene expression data. The text also describes applications of mode-oriented stochastic search algorithms, in vitro to in vivo factor profiling, proportional hazards regression using Bayesian kernel machines, and QTL mapping.

Focusing on design, statistical inference, and data analysis from a Bayesian perspective, this volume explores statistical challenges in bioinformatics data analysis and modeling and offers solutions to these problems. It encourages readers to draw on the evolving technologies and promote statistical development in this area of bioinformatics.

A propos du livre

À propos de l?auteur

Dipak K. Dey is a professor and head of the Department of Statistics at the University of Connecticut.

Samiran Ghosh is an assistant professor in the Department of Mathematical Sciences at Indiana University-Purdue University.

Bani K. Mallick is a professor of statistics and director of the Bayesian Bioinformatics Laboratory at Texas A&M University.

Détails de l'édition

• Éditeur: Chapman & Hall/CRC
• Date d'édition: 2010
• Langue: anglais
• ISBN 10: 1420070177
• ISBN 13: 9781420070170
• Reliure: Relié
• Nombre de pages: 440
• Éditeur: Dey Dipak K., Ghosh Samiran, Mallick Bani K.
• Coordonnées du fabricant: non disponible
• Personne responsable: gpsr@libri.de; gpsr@libri.de; ; Friedensallee 273; Hamburg; 22763; Allemagne