Carbohydrate Chemistry: Proven Synthetic Methods (1) - Couverture rigide

Couverture rigide

ISBN 10 : 1439866899 ISBN 13 : 9781439866894

Editeur : CRC Press Inc, 2011

Synopsis

Long gone are the days when synthetic publications included parallel preparative experiments to document reproducibility of the experimental protocols and when journals required such documentation. The new Proven Synthetic Methods Series addresses concerns to chemists regarding irreproducibility of synthetic protocols, lack of characterization data for new compounds, and inflated yields reported in many chemical communications—trends that have recently become a serious problem.

Volume One of Carbohydrate Chemistry: Proven Synthetic Methods includes more detailed versions of protocols previously published for the synthesis of oligosaccharides, C-glycosyl compounds, sugar nucleotides, click chemistry, thioglycosides, and thioimidates, among others. The compilation of protocols covers both common and less frequently used synthetic methods as well as examples of syntheses of selected carbohydrate intermediates with general utility. The major focus of this book is devoted to the proper practice of state-of-the-art preparative procedures, including:

• References to the starting materials used, reaction setup, work-up and isolation of products, followed by identification and proof of purity of the final material
• General information regarding convenience of operation and comments on safety issues
• Versatile and practically useful methods that have not received deserved, long-lasting recognition or that are difficult to access from their primary sources
• Copies of 1D NMR spectra of compounds prepared, showing purity of materials readers can expect

Exploring carbohydrate chemistry from the academic points of view, the Carbohydrate Chemistry: Proven Synthetic Methods Series provides a compendium of preparatively useful procedures checked by chemists from independent research groups.

A propos du livre

À propos de l'auteur

Series editor Pavol Kovác, Ph.D., Dr. h.c., with more than 40 years of experience in carbohydrate chemistry and more than 270 papers published in refereed scientific journals or books, is a strong promoter of good laboratory practices and a vocal critic of the publication of experimental chemistry lacking data that allows reproducibility. He obtained an MSc in Chemistry at Slovak Technical University in Bratislava (Slovakia) and a PhD in Organic Chemistry at the Institute of Chemistry, Slovak Academy of Sciences, Bratislava. After postdoctoral training at the Department of Biochemistry, Purdue University, Lafayette, Indiana (R. L. Whistler, advisor), he returned to the Institute of Chemistry and formed a group of synthetic carbohydrate chemists, active mainly in oligosaccharide chemistry, which put the Institute on the map for quality synthetic carbohydrate chemistry.

After relocating to the United States in 1981, he first worked at Bachem, Inc., Torrance, California, where he established a laboratory for production of oligonucleotides for the automated synthesis of DNA. In 1983 he joined the National Institutes of Health, where he is currently one of the Principal Investigators and Chief of the Section on Carbohydrates (NIDDK, Laboratory of Bioorganic Chemistry), the world’s oldest research group continuously working on chemistry, biochemistry, and immunology of carbohydrates, originally established by America’s greatest carbohydrate chemist, Claude S. Hudson. Dr. Kovác’s main interest is in development of conjugate vaccines for bacterial diseases from synthetic carbohydrate antigens.

À propos de la quatrième de couverture

Useful in the glycosciences, this book presents reliable protocols for the preparation of synthetic carbohydrates. Featuring worldwide contributors and a well-known series editor, the text presents new or older, not easy to find protocols generally useful to those interested in synthetic carbohydrate chemistry. Having an independent checker verify the experimental portion of the text to ensure reproducibility, the Proven Synthetic Method Series brings state-of-the-art of synthetic carbohydrate chemistry at par with general organic synthesis. Methods presented include more detailed versions of protocols that have been previously published and some new methods for the synthesis of a variety of carbohydrate derivatives.

Détails de l'édition

• Éditeur: CRC Press Inc
• Date d'édition: 2011
• Langue: anglais
• ISBN 10: 1439866899
• ISBN 13: 9781439866894
• Reliure: Relié
• Numéro d'édition: 1
• Nombre de pages: 436
• Éditeur: Kovac Paul
• Coordonnées du fabricant: non disponible
• Personne responsable: gpsr@libri.de; gpsr@libri.de; ; Europaallee 1; Bad Hersfeld; 36244; Allemagne