Electrostatic Considerations in Mitosis: Integrating Physics and Cell Biology in Mitosis - Couverture souple

Gagliardi, L John

Couverture souple

ISBN 10 : 1440173788 ISBN 13 : 9781440173783

Editeur : iUniverse, 2009

Synopsis

Identifying the motive force is central to explaining chromosome motions during mitosis. Presently, there is no consensus on what it is. The author has proposed a minimal assumptions model for the dynamics of post-attachment chromosome motions based on nanoscale electrostatics. Given the electrical properties of tubulin and the dynamic instability of microtubules, it is possible to account for prometaphase post-attachment, metaphase, and anaphase chromosome motions within a comprehensive model. The model addresses all of the following in a unified manner:

• Efficiency of aster and spindle assembly and the motive force for the motion of asters and forming half-spindles.
• Chromatid pair attachment.
• Motion of monovalently attached chromatid pairs.
• Motion of bivalently attached chromatid pairs and chromosome congression.
• Metaphase chromatid pair oscillations.
• Chromatid separation and anaphase-A chromosome motion.
• Anaphase-B pole separation.
• An ab-initio calculation of the maximum tension force exerted by a microtubule during mitosis that falls within the experimental range.
• Poleward force generation of chromosomes at poles with associated microtubule flux.

Détails de l'édition

• Éditeur: iUniverse
• Date d'édition: 2009
• Langue: anglais
• ISBN 10: 1440173788
• ISBN 13: 9781440173783
• Reliure: Broché
• Nombre de pages: 124
• Coordonnées du fabricant: non disponible
• Personne responsable: GPSR Kontakt; gpsr@libri.de; ; Europaallee 1; Bad Hersfeld; 36244; Allemagne