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The analysis of gene expression profile data from Dna micorarray studies are discussed in this book. It provides a review of available methods and presents it in a manner that is intelligible to biologists. It offers an understanding of the design and analysis of experiments utilizing microarrays to benefit scientists. It includes an Appendix tutorial on the use of Brb-ArrayTools and step by step analyses of several major datasets using this software which is available from the National Cancer Institute.
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- ÉditeurSpringer-Verlag New York Inc.
- Date d'édition2011
- ISBN 10 1441918027
- ISBN 13 9781441918024
- ReliureBroché
- Nombre de pages200
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Design and Analysis of DNA Microarray Investigations
Edité par
Springer New York Dez 2011
(2011)
ISBN 10 : 1441918027
ISBN 13 : 9781441918024
Neuf
Taschenbuch
Quantité disponible : 2
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Description du livre Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is targeted to biologists with limited statistical background and to statisticians and computer scientists interested in being effective collaborators on multi-disciplinary DNA microarray projects. State-of-the-art analysis methods are presented with minimal mathematical notation and a focus on concepts. This book is unique because it is authored by statisticians at the National Cancer Institute who are actively involved in the application of microarray technology.Many laboratories are not equipped to effectively design and analyze studies that take advantage of the promise of microarrays. Many of the software packages available to biologists were developed without involvement of statisticians experienced in such studies and contain tools that may not be optimal for particular applications. This book provides a sound preparation for designing microarray studies that have clear objectives, and for selecting analysis tools and strategies that provide clear and valid answers. The book offers an in depth understanding of the design and analysis of experiments utilizing microarrays and should benefit scientists regardless of what software packages they prefer. In order to provide all readers with hands on experience in data analysis, it includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is freely available from the National Cancer Institute for non-commercial use.The authors are current or former members of the Biometric Research Branch at the National Cancer Institute. They have collaborated on major biomedical studies utilizing microarrays and in the development of statistical methodology for the design and analysis of microarray investigations. Dr. Simon, chief of the branch, is also the architect of BRB-ArrayTools. 232 pp. Englisch. N° de réf. du vendeur 9781441918024
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Design and Analysis of DNA Microarray Investigations
Edité par
Springer New York
(2011)
ISBN 10 : 1441918027
ISBN 13 : 9781441918024
Neuf
Couverture souple
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Description du livre Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Targets to biologists with limited statistical background and to statisticians and computer scientists interested in being effective collaborators on multi-disciplinary DNA microarray projectsPresents state-of-the-art analysis methods with mi. N° de réf. du vendeur 4172379
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Design and Analysis of DNA Microarray Investigations
Edité par
Springer New York
(2011)
ISBN 10 : 1441918027
ISBN 13 : 9781441918024
Neuf
Taschenbuch
Quantité disponible : 1
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Description du livre Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - DNA microarrays are an important technology for studying gene expression. With a single hybridization, the level of expression of thousands of genes, or even an entire genome, can be estimated for a sample of cells. Consequently, manylaboratoriesareattemptingtoutilizeDNAmicroarraysintheirresearch. Whereaslaboratoriesarewellpreparedtoaddressthesigni cantexperimental challenges in obtaining reproducible data from this RNA-based assay, inv- tigators are less prepared to analyze the large volumes of data produced by DNA microarrays. Although many software packages have been developed for the analysis of DNA microarray data, software alone is insu cient. One needs knowledge aboutthevariousaspectsofdataanalysisinordertoselectandutilizesoftware e ectively. There is a plethora of analysis methods being published and it is di cult for biologists to determine which methods are valid and appropriate for their problems. Many scientists have learned that software is not an adequate substitute for biostatistical knowledge and seek statistical collaborators. Unfortunately, there is presently a shortage of statisticians who are available and knowled- able about DNA microarrays. For statisticians to be e ective collaborators in anyarea,theymustinvestthetimetounderstandthesubjectmatterareaand become familiar with the literature so that they can ask the right questions and identify the key issues. Our objectives in this book are twofold: to provide scientists with infor- tion about the design and analysis of studies using DNA microarrays that will enable them to plan and analyze their own studies or to work with statistical collaborators e ectively, and to aid statistical and computational scientists wishing to develop expertise in this area. N° de réf. du vendeur 9781441918024
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Design and Analysis of DNA Microarray Investigations (Statistics for Biology and Health)
Edité par
Springer
(2011)
ISBN 10 : 1441918027
ISBN 13 : 9781441918024
Neuf
Paperback
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Description du livre Paperback. Etat : Brand New. 2003 edition. 200 pages. 9.00x6.00x0.50 inches. In Stock. N° de réf. du vendeur zk1441918027
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