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Probability Models for DNA Sequence Evolution - Couverture souple

 
9781441926777: Probability Models for DNA Sequence Evolution

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This book presents mathematical techniques for understanding sequence evolution. The theory is developed in close connection with data from more than 60 experimental studies that illustrate the use of these results.

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  • ÉditeurSpringer
  • Date d'édition2010
  • ISBN 10 1441926771
  • ISBN 13 9781441926777
  • ReliureBroché
  • Langueanglais
  • Nombre de pages444

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9780387781686: Probability Models for DNA Sequence Evolution

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ISBN 10 :  0387781684 ISBN 13 :  9780387781686
Editeur : Springer-Verlag New York Inc., 2008
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Durrett, Richard
Edité par Springer, 2010
ISBN 10 : 1441926771 ISBN 13 : 9781441926777
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Paperback. Etat : Very Good. Second Edition. 2nd edition. Very good paperback copy. Spine is uncreased, binding tight and sturdy. Previous owner's stickers markered out on title page, otherwise text is very good. Bottom edge has black circle, presumably a remainder mark. Shelfwear is minor. A reprint edition of high quality. Ships from Dinkytown in Minneapolis, Minnesota. N° de réf. du vendeur 298249

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Durrett, Richard:
Edité par New York, Springer, 2010
ISBN 10 : 1441926771 ISBN 13 : 9781441926777
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Hardcover. 2nd Ed. xii, 431 S. Ehem. Bibliotheksexemplar mit Signatur und Stempel. GUTER Zustand, ein paar Gebrauchsspuren. Ex-library in GOOD condition with library-signature and stamp(s). Some traces of use. R-16979 9781441926777 Sprache: Englisch Gewicht in Gramm: 1050. N° de réf. du vendeur 2480296

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Durrett, Richard
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Durrett, Richard
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Richard Durrett
Edité par Springer New York Dez 2010, 2010
ISBN 10 : 1441926771 ISBN 13 : 9781441926777
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'What underlying forces are responsible for the observed patterns of variability, given a collection of DNA sequences ' In approaching this question a number of probability models are introduced and anyalyzed.Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies that illustrate the use of these results. Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigation of various statistical tests to detect departures from 'neutral evolution.' The final chapter studies the evolution of whole genomes by chromosomal inversions, reciprocal translocations, and genome duplication.Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies from the biology literature that illustrate the use of these results. This book is written for mathematicians and for biologists alike. We assume no previous knowledge of concepts from biology and only a basic knowledge of probability: a one semester undergraduate course and some familiarity with Markov chains and Poisson processes.Rick Durrett received his Ph.D. in operations research from Stanford University in 1976. He taught in the UCLA mathematics department before coming to Cornell in 1985. He is the author of six books and 125 research papers, and is the academic father of more than 30 Ph.D. students. His current interests are the use of probability models in genetics and ecology, and decreasing the mean and variance of his golf score. How is genetic variability shaped by natural selection, demographic factors, and random genetic drift To approach this question, we introduce and analyze a number of probability models beginning with the basics, and ending at the frontiers of current research. Throughout the book, the theory is developed in close connection with examples from the biology literature that illustrate the use of these results. Along the way, there are many numerical examples and graphs to illustrate the conclusions.This is the second edition and is twice the size of the first one. The material on recombination and the stepping stone model have been greatly expanded, there are many results form the last five years, and two new chapters on diffusion processes develop that viewpoint. This book is written for mathematicians and for biologists alike. No previous knowledge of concepts from biology is assumed, and only a basic knowledge of probability, including some familiarity with Markov chains and Poisson processes. The book has been restructured into a large number of subsections and written in a theorem-proof style, to more clearly highlight the main results and allow readers to find the results they need and to skip the proofs if they desire.Rick Durrett received his Ph.D. in operations research from Stanford University in 1976. He taught in the UCLA mathematics department before coming to Cornell in 1985. He is the author of eight books and 160 research papers, most of which concern the use of probability models in genetics and ecology. He is the academic father of 39 Ph.D. students and was recently elected to the National Academy of Sciences. 444 pp. Englisch. N° de réf. du vendeur 9781441926777

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Richard Durrett
Edité par Springer New York, 2010
ISBN 10 : 1441926771 ISBN 13 : 9781441926777
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigation of various statistical tests to detect departures from 'neutral evolution'. The final chapter studies the evolution of whole genomes by chromosomal inversions, reciprocal translocations, and genome duplication.Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies from the biology literature that illustrate the use of these results. This book is written for mathematicians and for biologists alike. We assume no previous knowledge of concepts from biology and only a basic knowledge of probability: a one semester undergraduate course and some familiarity with Markov chains and Poisson processes. N° de réf. du vendeur 9781441926777

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Paperback / softback. Etat : New. This item is printed on demand. New copy - Usually dispatched within 5-9 working days 694. N° de réf. du vendeur C9781441926777

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