Integration of Pharmaceutical Discovery and Development: Case Histories - Couverture souple

Couverture souple

ISBN 10 : 1441932887 ISBN 13 : 9781441932884

Editeur : Springer-Verlag New York Inc., 2010

Synopsis

In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g., high affinity and specificity for the target receptor), pharmaceutical (e. g., solubility and chemical stability), bioph- maceutical (e. g., cell membrane permeability), and metabolic/pharmacokinetic (e. g., metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g., medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g., analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.

Détails de l'édition

• Éditeur: Springer-Verlag New York Inc.
• Date d'édition: 2010
• Langue: anglais
• ISBN 10: 1441932887
• ISBN 13: 9781441932884
• Reliure: Broché
• Nombre de pages: 639
• Éditeur: Borchardt Ronald T., Freidinger Roger M., Sawyer Tomi K., Smith Philip L.
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne