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Multistate GTPase Control Co-translational Protein Targeting: Doctoral Thesis for Chemistry Accepted by California Institute of Technology, Pasadena, Ca, USA - Couverture rigide
Synopsis
Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.
Written while completing graduate work at California Institute of Technology.
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À propos de l?auteur
Xin Zhang, PhD, received his Doctorate from The California Institute of Technology and now works at The Scripps Research Institute
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Multistate GTPase Control Co-translational Protein Targeting
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Springer US, 2011
ISBN 10 : 1441978070
ISBN 13 : 9781441978073
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Multistate GTPase Control Co-translational Protein Targeting
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Springer US Sep 2011, 2011
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ISBN 13 : 9781441978073
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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.Written while completing graduate work at California Institute of Technology. 104 pp. Englisch. N° de réf. du vendeur 9781441978073
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Multistate GTPase Control Co-translational Protein Targeting
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ISBN 10 : 1441978070
ISBN 13 : 9781441978073
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Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.Written while completing graduate work at California Institute of Technology. N° de réf. du vendeur 9781441978073
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Multistate GTPase Control Co-translational Protein Targeting
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Springer New York, Springer US Sep 2011, 2011
ISBN 10 : 1441978070
ISBN 13 : 9781441978073
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Buch. Etat : Neu. Neuware -Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.Written while completing graduate work at California Institute of Technology.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 104 pp. Englisch. N° de réf. du vendeur 9781441978073
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Multistate GTPase Control Co-translational Protein Targeting (Springer Theses)
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Multistate GTPase Control Co-translational Protein Targeting: Doctoral Thesis for Chemistry Accepted by California Institute of Technology, Pasadena, Ca, USA
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