Articles liés à Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Synopsis
This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
À propos de l?auteur
Peter Bonate has 16 years industrial experience, 13 years as a clinical pharmacologist/pharmacokineticist and three years in drug metabolism and bioanalysis. He is currently a Director in the Clinical Pharmacology, Modeling, and Simulation department at GlaxoSmithKline in the oncology and rare diseases therapeutic areas. He has worked at Genzyme, Hoechst Marion Roussel, Eli Lilly, and Quintiles. He received his PhD in 1996 from Indiana University in Medical Neurobiology with an emphasis on the pharmacokinetics of drugs of abuse. He received an MS in statistics from the University of Idaho and an MS in Pharmacology from Washington State University, both in 1990. In 2003 he was elected a Fellow of the American College of Clinical Pharmacology and in 2007 was elected a fellow of the American Association of Pharmaceutical Scientists (AAPS). He was founder of the Modeling and Simulation focus group, has served as chair of the population pharmacokinetics focus group, and was the Clinical Pharmacology and Translational Research Section Chair within AAPS. He has served or currently serves on the editorial boards for the Journal of Clinical Pharmacology, Pharmaceutical Research, Journal of Pharmacokinetics and Pharmacodynamics, and The AAPS Journal. He has more than 50 publications in the field of pharmacokinetics and clinical pharmacology, is co-editor of the 3-volume series Pharmacokinetics in Drug Development published by AAPS Press in 2004 and 2011, and is author of the book Pharmacokinetic-Pharmacodynamic Modeling and Simulation published by Springer in 2006. In 2010, he became an Adjunct Assistant Professor at the Indiana University School of Medicine and the University of North Carolina, Chapel Hill.
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Pharmacokinetic-Pharmacodynamic Modeling and Simulation
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Springer, 2011
ISBN 10 : 144199484X
ISBN 13 : 9781441994844
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Etat : Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1900grams, ISBN:9781441994844. N° de réf. du vendeur 5806160
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Pharmacokinetic-Pharmacodynamic Modeling and Simulation (Hardcover)
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ISBN 10 : 144199484X
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Hardcover. Etat : new. Hardcover. This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. N° de réf. du vendeur 9781441994844
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Pharmacokinetic-Pharmacodynamic Modeling and Simulation
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ISBN 10 : 144199484X
ISBN 13 : 9781441994844
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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since its publication in 2006, Pharmacokinetic-Pharmacodynamic Modeling and Simulation has become the leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models and has been championed by students and teachers for its readability and exposition of complex statistical topics. Using a building block approach, the text starts with linear regression, nonlinear regression, and variance models at the individual level and then moves to population-level models with linear and nonlinear mixed effects models. Particular emphasis is made highlighting relationships between the model types and how the models build upon one another. With the second edition, new chapters on generalized nonlinear mixed effects models and Bayesian models are presented, along with an extensive chapter on simulation. In addition, many chapters have been updated to reflect recent developments since the first edition. The theory behind the methods is illustrated using real data from the literature and from the author's experiences in drug development. Data are analyzed using a variety of software, including NONMEM, SAS, SAAM II, and WinBUGS. A key component of the book is to show how models are developed using an acceptance-rejection paradigm with the ultimate goal of using models to explain data, summarize complex experiments, and use simulation to answer 'what-if' questions. Although the book is written towards pharmaceutical scientists, scientists, statisticians, and mathematicians outside the field will find the book invaluable in understanding complex statistical modeling and simulation. This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated. 640 pp. Englisch. N° de réf. du vendeur 9781441994844
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Pharmacokinetic-Pharmacodynamic Modeling and Simulation
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ISBN 10 : 144199484X
ISBN 13 : 9781441994844
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Buch. Etat : Neu. Neuware -This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 640 pp. Englisch. N° de réf. du vendeur 9781441994844
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Pharmacokinetic-Pharmacodynamic Modeling and Simulation
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Pharmacokinetic-Pharmacodynamic Modeling and Simulation
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Springer US, Springer US, 2011
ISBN 10 : 144199484X
ISBN 13 : 9781441994844
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Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Since its publication in 2006, Pharmacokinetic-Pharmacodynamic Modeling and Simulation has become the leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models and has been championed by students and teachers for its readability and exposition of complex statistical topics. Using a building block approach, the text starts with linear regression, nonlinear regression, and variance models at the individual level and then moves to population-level models with linear and nonlinear mixed effects models. Particular emphasis is made highlighting relationships between the model types and how the models build upon one another. With the second edition, new chapters on generalized nonlinear mixed effects models and Bayesian models are presented, along with an extensive chapter on simulation. In addition, many chapters have been updated to reflect recent developments since the first edition. The theory behind the methods is illustrated using real data from the literature and from the author's experiences in drug development. Data are analyzed using a variety of software, including NONMEM, SAS, SAAM II, and WinBUGS. A key component of the book is to show how models are developed using an acceptance-rejection paradigm with the ultimate goal of using models to explain data, summarize complex experiments, and use simulation to answer 'what-if' questions. Although the book is written towards pharmaceutical scientists, scientists, statisticians, and mathematicians outside the field will find the book invaluable in understanding complex statistical modeling and simulation. This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated. N° de réf. du vendeur 9781441994844
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Pharmacokinetic-Pharmacodynamic Modeling and Simulation
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Pharmacokinetic-Pharmacodynamic Modeling and Simulation
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Pharmacokinetic-Pharmacodynamic Modeling and Simulation (Hardcover)
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Springer-Verlag New York Inc., New York, NY, 2011
ISBN 10 : 144199484X
ISBN 13 : 9781441994844
Neuf
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Hardcover. Etat : new. Hardcover. This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. N° de réf. du vendeur 9781441994844
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