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Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications - Couverture souple
Synopsis
The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: - size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . - potential tumorigenesis (e. g. retrovirus) - potential for insertional mutagenesis (greater than plasmid based systems) - potential imrnunogenicity (e. g.
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Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications (Developments in Cardiovascular Medicine, 189)
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Gene Transfer in the Cardiovascular System (Paperback)
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Paperback. Etat : new. Paperback. The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . potential tumorigenesis (e. g. retrovirus) potential for insertional mutagenesis (greater than plasmid based systems) potential imrnunogenicity (e. g. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. N° de réf. du vendeur 9781461378815
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Gene Transfer in the Cardiovascular System
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expr. N° de réf. du vendeur 4196000
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Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications (Developments in Cardiovascular Medicine, 189)
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled 'Artificial Self-Assembling Systems for Gene Transfer', brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: - size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . - potential tumorigenesis (e. g. retrovirus) - potential for insertional mutagenesis (greater than plasmid based systems) - potential imrnunogenicity (e. g. 540 pp. Englisch. N° de réf. du vendeur 9781461378815
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Gene Transfer in the Cardiovascular System : Experimental Approaches and Therapeutic Implications
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Gene Transfer in the Cardiovascular System : Experimental Approaches and Therapeutic Implications
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ISBN 10 : 1461378818
ISBN 13 : 9781461378815
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Gene Transfer in the Cardiovascular System
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled 'Artificial Self-Assembling Systems for Gene Transfer', brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: ¿ size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . ¿ potential tumorigenesis (e. g. retrovirus) ¿ potential for insertional mutagenesis (greater than plasmid based systems) ¿ potential imrnunogenicity (e. g.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 540 pp. Englisch. N° de réf. du vendeur 9781461378815
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Gene Transfer in the Cardiovascular System : Experimental Approaches and Therapeutic Implications
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled 'Artificial Self-Assembling Systems for Gene Transfer', brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: - size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . - potential tumorigenesis (e. g. retrovirus) - potential for insertional mutagenesis (greater than plasmid based systems) - potential imrnunogenicity (e. g. N° de réf. du vendeur 9781461378815
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Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications
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